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首页> 外文期刊>Life sciences >High-dose tranilast administration to rats creates interstitial cystitis-like symptoms with increased vascular permeability
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High-dose tranilast administration to rats creates interstitial cystitis-like symptoms with increased vascular permeability

机译：对大鼠的高剂量胸盆助理给予大鼠的间质膀胱炎样症状，血管渗透性增加

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摘要

Aim We investigated whether the high-dose administration of tranilast could be used to create an animal model of interstitial cystitis (IC). Then, we used this model to assess the relationship between IC and changes in the vascular permeability of the bladder. Main methods Female rats were divided into the following 4 groups: a control group, a tranilast group, a carbazochrome group and a combination (tranilast + carbazochrome) group. Continuous cystometry, bladder distension, and the Evans blue dye extravasation test were performed 4 weeks after drug administration. Locomotor activity, the plasma TGF-β1 level, and collagen fibers in the bladder wall were also examined in the control and tranilast groups. Key findings The interval between bladder contractions was shorter and the leakage of Evans blue dye into the bladder wall was greater in the tranilast group than in the control group. Glomerulations of the bladder wall after bladder distention and thinning of the collagen fiber layer in the bladder were observed in the tranilast group. Locomotor activity in darkness and the plasma TGF-β1 level were both lower in the tranilast group than in the control group. In the combination group, the leakage of Evans blue dye was greater than in the control group; however, it was less prominent than in the tranilast group. Significance These results suggest that high-dose administration of tranilast to rats can create an IC-like rat model and that an increase in the vascular permeability of the bladder wall may be one cause of IC symptoms.
机译：目的我们研究了疏水蓟的高剂量施用是否可用于制造间质膀胱炎（IC）的动物模型。然后，我们使用该模型来评估IC与膀胱血管渗透性之间的关系。主要方法雌性大鼠分为以下4组：对照组，旋转组，猪血目组和组合（Tranilast + Carbazochrome）组。在药物管理后4周进行连续囊体，膀胱膨胀和evans蓝染料外渗试验。在对照和旋转壁组中也检查了运动活性，血浆TGF-β1水平和膀胱壁中的胶原纤维。主要发现膀胱收缩之间的间隔较短，埃文斯蓝染料进入膀胱壁的泄漏比对照组更大。在Tranilast组中观察到膀胱膨胀和胶原纤维层中胶粘剂纤维层的膀胱膨胀和稀疏的肾脏。在黑暗中的运动活性和血浆TGF-β1水平均在Tranilast组中均低于对照组。在组合组中，埃文斯蓝染料的泄漏大于对照组;然而，它比在胸斗组织中突出。这些结果表明，高剂量施用对大鼠的大鼠可以产生IC样大鼠模型，并且膀胱壁的血管通透性的增加可能是IC症状的一种原因。

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  • 来源
    《Life sciences》 |2013年第23期|共7页
  • 作者

    NishijimaS.; SugayaK.; KadekawaK.; AshitomiK.; UedaT.; YamamotoH.;

  • 作者单位

    Southern Knights' Laboratory LLP 2-7-7-301 Takahara Okinawa 904-2171 Japan;

    Southern Knights' Laboratory LLP 2-7-7-301 Takahara Okinawa 904-2171 Japan;

    Southern Knights' Laboratory LLP 2-7-7-301 Takahara Okinawa 904-2171 Japan;

    Southern Knights' Laboratory LLP 2-7-7-301 Takahara Okinawa 904-2171 Japan;

    Institute for Animal Experiments Faculty of Medicine University of the Ryukyus Okinawa Japan;

    Department of Biochemistry Graduate School of Medicine University of the Ryukyus Okinawa Japan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Interstitial cystitis; Tranilast; Vascular permeability;

    机译：间质膀胱炎;旋转血管渗透性;

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