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Toll like receptor 4 and hepatocellular carcinoma; A systematic review

机译：损伤像受体4和肝细胞癌; 系统评价

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Abstract Introduction Toll like receptor 4 (TLR4) is an extracellular pathogen recognition receptor (PRR) which recognizes a wide range of pathogens and damage associated molecular patterns (PAMPs and DAMPs). It can activate intracellular signaling and consequently transcription factors which participate in transcription from either immune related or malignancy genes. Thus, it has been hypothesized that TLR4 may be a cause of hepatocellular carcinoma (HCC). This article has reviewed the roles of TLR4 in the pathogenesis of HCC. Method “TLR4”, “hepatocellular carcinoma”, “liver tumor” and “liver cancer” were used as key words for searching in Scopus, Google Scholar and MEDLINE scientific databases. Results Most of the investigations documented the roles of TLR4 in induction of HCC via several mechanisms including increased number of T regulatory lymphocytes and liver resident follicular helper like cells, increased production of pro-inflammatory and malignancy related molecules including cytokines, NANOG, Caspase-1, Ephrin-A1, NO and BCL6. TLR4 participates in the proliferation of the cells and also production of the molecules in both chronic infectious and non-infectious inflammatory diseases. Discussion TLR4 is an innate immunity receptor which plays a pathogenic role during chronic inflammation and can induce HCC in human. Graphical abstract Display Omitted
机译：摘要介绍受体4（TLR4）的损伤是一种细胞外病原菌识别受体（PRR），其识别出各种病原体和损伤相关的分子模式（PAMPS和DAMP）。它可以激活细胞内信号传导，从而激活从免疫相关或恶性基因的转录转录的转录因子。因此，已经假设TLR4可以是肝细胞癌（HCC）的原因。本文审查了TLR4在HCC发病机制中的作用。方法“TLR4”，“肝细胞癌”，“肝脏肿瘤”和“肝癌”被用作搜寻在Scopus，Google Scholar和Medline Scientific数据库中的关键词。结果大多数调查记录了TLR4通过几种机制诱导HCC在HCC诱导中的作用，包括细胞，增加了促炎和恶性肿瘤，包括细胞因子，纳米酶，Caspase-1的促炎和恶性肿瘤相关分子的产生增加，ephrin-a1，no和bcl6。 TLR4参与细胞的增殖以及在慢性传染性和非传染性炎症疾病中产生分子。讨论TLR4是一种先天免疫受体，其在慢性炎症期间发挥致病作用，并且可以在人体中诱导HCC。省略了图形抽象显示

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