Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy-induced osteoporosis

Wu Jia-Lin; Tsai Wei-Yuan; Chen Jian-Horng; Wong Chih-Shung

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Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy-induced osteoporosis

机译：右旋甲甲烷上调成骨细胞和骨壳活性，但不衰减卵巢切除术诱导的骨质疏松症

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Aims: Study on the in vivo regulatory role of glutamate in osteoblast (OB) and osteoclast (OC) differentiation is less advanced. The present study investigated the effect of dextromethorphan (DXM), an N-methyl-D-aspartate receptors (NMDARs) antagonist, on osteoporosis development.

机译：目的：研究谷氨酸在成骨细胞（OB）中的体内调节作用（OB）和破骨细胞（OC）分化不太先进。本研究研究了右旋菌（DXM），N-甲基-D-天冬氨酸受体（NMDARS）拮抗剂对骨质疏松症发育的影响。

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来源
《Life sciences》 |2017年第2017期|共5页
作者
Wu Jia-Lin; Tsai Wei-Yuan; Chen Jian-Horng; Wong Chih-Shung;
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作者单位

Taipei Med Univ Coll Med Sch Med Dept Orthoped Taipei Taiwan;

Cathay Gen Hosp Dept Anesthesiol 280 Renai Rd Sect 4 Taipei Taiwan;

Chung Shan Med Univ Sch Phys Therapy Taichung Taiwan;

Cathay Gen Hosp Dept Anesthesiol 280 Renai Rd Sect 4 Taipei Taiwan;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Osteoporosis; Dextromethorphan; Glutamate; Osteoblast; Osteoclast;

机译：骨质疏松症;葡萄球菌;谷氨酸;成骨细胞;破骨细胞;

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专利

1. Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy-induced osteoporosis [J] . Wu Jia-Lin, Tsai Wei-Yuan, Chen Jian-Horng, Life sciences . 2017,第期

机译：右旋甲甲烷上调成骨细胞和骨壳活性，但不衰减卵巢切除术诱导的骨质疏松症
2. Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling [J] . Alexander Bartelt, Friederike Behler-Janbeck, F. Timo Beil, Bone research . 2018,第1期

机译：成骨细胞中的Lrp1通过限制PDGF-RANKL信号传导来控制破骨细胞活性并预防骨质疏松
3. Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling [J] . Alexander Bartelt, Friederike Behler-Janbeck, F.Timo Beil, 骨研究：英文 . 2018,第001期

机译：成骨细胞中的Lrp1通过限制PDGF-RANKL信号传导来控制破骨细胞活性并预防骨质疏松
4. THE EFFECTS OF DEMINERALIZED BONE MATRIX PROTEINS, ESTROGEN, AND AN ANTAGONIST TO NEUROPEPTIDE Y ON OSTEOBLAST AND OSTEOCLAST VIABILITY AND FUNCTION RELATED TO OSTEOPOROSIS [C] . Jill White, Vince Morton, Kcndra Whittington, International ISA biomedical sciences instrumentation symposium;Annual rocky mountain bioengineering symposium . 2012

机译：异化骨基质蛋白，雌激素和神经肽Y拮抗剂对成骨细胞和破骨细胞活性以及与骨质疏松有关的功能的影响
5. The Molecular and Epigenetic Regulation of Osteoblast and Osteoclast Differentiation and the Implications in Osteoporosis. [D] . Yu, Bo. 2015

机译：成骨细胞和破骨细胞分化的分子和表观遗传调控及其在骨质疏松症中的意义。
6. Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling [O] . Alexander Bartelt, Friederike Behler-Janbeck, F. Timo Beil, 2018

机译：成骨细胞中的Lrp1通过限制PDGF-RANKL信号传导来控制破骨细胞活性并预防骨质疏松
7. Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling [O] . Alexander Bartelt, Friederike Behler-Janbeck, F. Timo Beil, 2018

机译：Osteooburblast中的LRP1通过限制PDGF-RANKL信号传导来控制骨蛋白活性并防止骨质疏松症

Dextromethorphan upregulates osteoblast and osteoclast activity but does not attenuate ovariectomy-induced osteoporosis

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