Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers

Goswami Sumanta Kumar; Rand Amelia Ann; Wan Debin; Yang Jun; Inceoglu Bora; Thomas Melany; Morisseau Christophe; Yang Guang-Yu; Hammock Bruce D.

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Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers

机译：可溶性环氧化物水解酶或遗传缺失的药理抑制减少了双氯芬酸诱导的胃溃疡

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摘要

Aims: This research was conducted to evaluate the hypothesis that gastric ulcers caused by the NSAID diclofenac sodium (DCF) can be prevented by the soluble epoxide hydrolase inhibitor TPPU.

机译：目的是进行该研究以评估由NSAID双氯芬酸钠（DCF）引起的胃溃疡可以通过可溶的环氧化物水解酶抑制剂TPPU来预防胃溃疡。

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来源
《Life sciences》 |2017年第2017期|共9页
作者
Goswami Sumanta Kumar; Rand Amelia Ann; Wan Debin; Yang Jun; Inceoglu Bora; Thomas Melany; Morisseau Christophe; Yang Guang-Yu; Hammock Bruce D.;
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作者单位

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

Northwestern Univ Dept Pathol Feinberg Sch Med 303 East Chicago Ave Chicago IL 60611 USA;

Univ Calif Davis Dept Entomol &

Nematol One Shields Ave Davis CA 95616 USA;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Diclofenac; Soluble epoxide hydrolase inhibitor TPPU; Stomach ulcer; Apoptosis; TNF-alpha; IL-6;

机译：Diclofenac;可溶性环氧化物水解酶抑制剂TPPU;胃溃疡;细胞凋亡;TNF-α;IL-6;

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专利

1. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers [J] . Goswami Sumanta Kumar, Rand Amelia Ann, Wan Debin, Life sciences . 2017,第期

机译：可溶性环氧化物水解酶或遗传缺失的药理抑制减少了双氯芬酸诱导的胃溃疡
2. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. [J] . Luo P, Chang HH, Zhou Y, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2010,第2期

机译：抑制或删除可溶性环氧化物水解酶可防止高血糖症，促进胰岛素分泌并减少胰岛细胞凋亡。
3. Effects of pharmacological inhibition of the hydrolase activity of soluble epoxide hydrolase in a rat model of pulmonary hypertension associated with cardiac insufficiency [J] . Fundamental & clinical pharmacology. . 2019,第S1期

机译：药理抑制水解酶活性的影响溶解环氧化物水解酶的大鼠肺动脉高血压大鼠模型中的心脏功能不全
4. INHIBITION OF EPOXIDE HYDROLASES AND GLUTATHIONE S-TRANSFERASE BY 2-, 3- AND 4-SUBSTITUTED DERIVATIVES OF 4-PHENYLCHALCONE AND ITS EPOXIDE [C] . T. Miyamoto, M. Sylva, B.D. Hammock International Congress of Pesticide Chemistry . 1986

机译：抑制环氧化物水解酶和谷胱甘肽S转移酶的2-，3-和4-取代的4-苯基凝块及其环氧化物的衍生物
5. Combinatorial Treatment of Diazepam and Soluble Epoxide Hydrolase Inhibition Stops Seizures and Modulates the Neuroinflammatory Response in a Murine Model of TETS Intoxication. [D] . Vito, Stephen Thomas. 2014

机译：地西p和可溶性环氧化物水解酶抑制的组合治疗可阻止癫痫发作并调节TETS中毒小鼠模型的神经炎症反应。
6. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers [O] . Sumanta Kumar Goswami, Amelia Ann Rand, Debin Wan, -1

机译：药理学抑制可溶性环氧化物水解酶或遗传删除减少双氯芬酸诱导的胃溃疡
7. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers [O] . Sumanta Kumar Goswami, Amelia Ann Rand, Debin Wan, 2017

机译：可溶性环氧化物水解酶或遗传缺失的药理抑制减少了双氯芬酸诱导的胃溃疡

Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers

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