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Pathophysiological mechanisms involved in the relationship between diabetes and major depressive disorder

机译：糖尿病与重大抑郁症关系的病理生理机制

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Abstract Diabetes mellitus (DM) and major depressive disorder (MDD) are diseases that are expanding globally. Separately, each presents with several comorbidities for patients. When the two diseases present simultaneously in the same subject, there is a drastic worsening in the quality of life of the patient. This study reviewed the literature relating to the relationship between MDD and DM, bringing forward studies showing that DM develops due to MDD, and others that report the opposite. According to the studies reviewed, DM and MDD are both debilitating conditions that are associated with significant morbidity, mortality, and healthcare costs. When these two diseases coexist, the association results in a decreased adherence to treatment, poor metabolic control, higher rates of complications, a decrease in the quality of life for the patient, increased healthcare use and cost, increased disability and lost productivity, and an increased risk of death. Therefore, it becomes essential that there are larger studies targeting the association of these two diseases, as for the patient, preventing even one of them will ensure improvements in their quality of life. Graphical abstract The main pathological changes shared by depression and diabetes are elevated levels of inflammation and glucose levels, and hypothalamic–pituitary–adrenal (HPA) axis activation. Display Omitted ]]>
机译：摘要糖尿病（DM）和主要抑郁症（MDD）是在全球扩展的疾病。另外，每个都有几种患者的合并症。当两种疾病同时存在于同一主题时，患者的生命质量存在急剧恶化。本研究综述了与MDD和DM之间关系有关的文献，提出了表现出DM由于MDD而发展的研究以及报告相反的其他研究。根据审查的研究，DM和MDD既具有明显的发病率，死亡率和医疗费用有关的衰弱条件。当这两种疾病共存时，关联导致治疗的粘附性降低，代谢控制差，并发症率较高，患者的生活质量降低，增加医疗保健使用和成本，患病程度增加，生产力增加，以及损失和损失的生产力，增加，损失和损失，生产力增加，损失，生产力增加，损失增加，损失和生产力损失，增加增加死亡风险。因此，存在靶向这两种疾病的关联的较大研究至关重要，如患者，预防其中一个疾病将确保改善他们的生活质量。图形摘要抑郁和糖尿病共享的主要病理变化是炎症和葡萄糖水平的升高，下丘脑 - 垂体 - 肾上腺（HPA）轴激活。显示省略]]]>

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