ABCA1 affects placental function via trophoblast and macrophage

Xie Chengmao; Lin Li; Long Yan; Yang Jie; Wang Xiaoju; Cai Xiaohui; Guan Huimin

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ABCA1 affects placental function via trophoblast and macrophage

机译：ABCA1通过滋养细胞和巨噬细胞影响胎盘功能

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Abstract Aims To study the potential impact of ABCA1 on the function of the placenta. Main methods Trophoblasts and macrophages were isolated from the placenta with enzymatic digestion; Immunofluorescence assay was used to detect the location of ABCA1 in cells; RT-PCR and Western-blot were used to detect the expression of ABCA1; The cholesterol efflux assays of primary trophoblasts was detected by Amplex Red cholesterol assay kit (Invitrogen);Inflammatory factor secretion from primary macrophages was detected by Elisa. Key findings ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P Significance ABCA1 may be a potential target for the prevention of gestation diseases.

机译：摘要旨在研究ABCA1对胎盘功能的潜在影响。主要方法与酶消化的胎盘分离滋养细胞和巨噬细胞; 使用免疫荧光测定检测细胞中ABCA1的位置; RT-PCR和Western-Blot检测ABCA1的表达; 通过Ampered Red Choleter醇测定试剂盒（Invitrogen）检测原发性滋养细胞的胆固醇流出测定; ELISA检测来自原发性巨噬细胞的炎症因子分泌物。主要发现ABCA1主要位于滋养管膜上。降低滋养细胞中的ABCA1表达降低了滋养细胞的胆固醇渗透（P意义ABCA1可能是预防妊娠疾病的潜在靶标。

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来源
《Life sciences》 |2017年第2017期|共7页
作者
Xie Chengmao; Lin Li; Long Yan; Yang Jie; Wang Xiaoju; Cai Xiaohui; Guan Huimin;
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作者单位

Department of Gynecology &

Obstetrics Beijing Friendship Hospital Capital Medical University;

Department of Gynecology &

Obstetrics Peking University International Hospital;

Department of Gynecology &

Obstetrics Beijing Friendship Hospital Capital Medical University;

Department of Gynecology &

Obstetrics Beijing Friendship Hospital Capital Medical University;

Department of Gynecology &

Obstetrics Beijing Friendship Hospital Capital Medical University;

Department of Gynecology &

Obstetrics Beijing Friendship Hospital Capital Medical University;

Department of Gynecology &

Obstetrics Beijing Friendship Hospital Capital Medical University;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
ABCA1; Cholesterol; Anti-inflammatory; Placenta; Gestation diseases;

机译：ABCA1;胆固醇;抗炎;胎盘;妊娠疾病;

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专利

1. ABCA1 affects placental function via trophoblast and macrophage [J] . Xie Chengmao, Lin Li, Long Yan, Life sciences . 2017,第期

机译：ABCA1通过滋养细胞和巨噬细胞影响胎盘功能
2. 2005 Trophoblast Research Award Lecture: Defects in the keratin cytoskeleton disrupt normal murine placental development and trophoblast cell function. [J] . Watson ED Placenta . 2007,第Suppla1期

机译：2005年滋养细胞研究奖演讲：角蛋白细胞骨架中的缺陷破坏了正常的小鼠胎盘发育和滋养细胞功能。
3. Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia [J] . Yoshiki Kudo, C. A. R. Boyd, I. L. Sargent, Biochimica et biophysica acta. Molecular basis of disease: BBA . 2003,第1期

机译：缺氧改变人胎盘BeWo细胞的滋养层细胞融合过程中合体素及其受体的表达和功能：先兆子痫对滋养层合胞体受损的影响
4. Bisphenols and Placental Trophoblast Dysfunction [C] . Almudena Veiga-Lopez Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：双酚与胎盘滋养细胞功能异常
5. PKA Signaling in ABCA1 Function: A Role in Modulation of Cholesterol Efflux and Macrophage Inflammation. [D] . Ma, Loretta. 2013

机译：ABCA1功能中的PKA信号传导：在胆固醇外流和巨噬细胞炎症调节中的作用。
6. Haplotype-dependent Differential Activation of the Human IL-10 Gene Promoter in Macrophages and Trophoblasts: Implications for Placental IL-10 Deficiency and Pregnancy Complications [O] . Surendra Sharma, Joan Stabila, Linda Pietras, -1

机译：单倍型依赖于巨噬细胞和滋养细胞中的人IL-10基因启动子的差异激活：对胎盘IL-10缺乏和妊娠并发症的影响
7. Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. [O] . Kudo, Y, Boyd, CA, Sargent, IL, 2003

机译：缺氧改变人胎盘BeWo细胞的滋养层细胞融合过程中合体素及其受体的表达和功能：先兆子痫中滋养层合胞体受损的影响。

ABCA1 affects placental function via trophoblast and macrophage

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