Prediction of Core Signaling Pathway by Using Diffusion-and Perfusion-based MRI Radiomics and Next-generation Sequencing in Isocitrate Dehydrogenase Wild-type Glioblastoma

Park Ji Eun; Kim Ho Sung; Park Seo Young; Nam Soo Jung; Chun Sung-Min; Jo Youngheun; Kim Jeong Hoon

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Prediction of Core Signaling Pathway by Using Diffusion-and Perfusion-based MRI Radiomics and Next-generation Sequencing in Isocitrate Dehydrogenase Wild-type Glioblastoma

机译：采用基于扩散和灌注的MRI辐射瘤及其在异柠檬酸脱氢酶野生型胶质母细胞瘤中的下一代测序预测核心信号传导途径

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Background: Next-generation sequencing (NGS) enables highly sensitive cancer genomics analysis, but its clinical implications for therapeutic options from imaging-based prediction have been limited.

机译：背景：下一代测序（NGS）使得能够高敏感的癌症基因组学分析，但其对基于成像的预测的治疗选择的临床意义受到限制。

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来源
《Radiology》 |2020年第2期|共10页
作者
Park Ji Eun; Kim Ho Sung; Park Seo Young; Nam Soo Jung; Chun Sung-Min; Jo Youngheun; Kim Jeong Hoon;
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作者单位

Univ Ulsan Coll Med Asan Med Ctr Dept Radiol 43 Olymp Ro 88 Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Radiol 43 Olymp Ro 88 Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Clin Epidemiol &

Biostat 43 Olymp Ro 88 Seoul 05505;

Univ Ulsan Coll Med Asan Med Ctr Dept Pathol 43 Olymp Ro 88 Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Pathol 43 Olymp Ro 88 Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Radiol 43 Olymp Ro 88 Seoul 05505 South Korea;

Univ Ulsan Coll Med Asan Med Ctr Dept Neurosurg 43 Olymp Ro 88 Seoul 05505 South Korea;

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正文语种 eng
中图分类放射医学;
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1. Prediction of Core Signaling Pathway by Using Diffusion-and Perfusion-based MRI Radiomics and Next-generation Sequencing in Isocitrate Dehydrogenase Wild-type Glioblastoma [J] . Park Ji Eun, Kim Ho Sung, Park Seo Young, Radiology . 2020,第2期

机译：采用基于扩散和灌注的MRI辐射瘤及其在异柠檬酸脱氢酶野生型胶质母细胞瘤中的下一代测序预测核心信号传导途径
2. ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data [J] . Nalee Kim, Se Hoon Kim, Seok-Gu Kang, Radiation oncology . 2020,第1期

机译：ATM突变在野生型异硝酸盐脱氢酶相关高级胶质瘤中提高无线电敏感性：使用下一代测序数据的回顾性分析
3. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities [J] . Sejin Oh, Jeonghun Yeom, Hee Jin Cho, Nature Communications . 2020,第1期

机译：集成的药物 - 蛋白质元素描述了同种核酸脱氢酶野生型胶质母细胞瘤的两个亚组，具有预后和治疗机会
4. Overall Survival Prediction for Glioblastoma on Pre-treatment MRI Using Robust Radiomics and Priors [C] . Yannick Suter, Urspeter Knecht, Roland Wiest, International Workshop on Brain-Lesion;Medical Image Computing and Computer Assisted Intervention Conference . 2020

机译：使用鲁棒的射线瘤和前沿对预处理MRI进行胶质母细胞瘤的总体存活预测
5. ATM mutations improve radio-sensitivity in wild-type isocitrate dehydrogenase-associated high-grade glioma: retrospective analysis using next-generation sequencing data [O] . Nalee Kim, Se Hoon Kim, Seok-Gu Kang, 2020

机译：ATM突变在野生型异硝酸盐脱氢酶相关高级胶质瘤中提高无线电敏感性：使用下一代测序数据的回顾性分析
6. Less Invasive Phenotype Found in Isocitrate Dehydrogenase-mutated Glioblastomas than in Isocitrate Dehydrogenase Wild-Type Glioblastomas: A Diffusion-Tensor Imaging Study [O] . Price Stephen John, Allinson K, Liu H, 2017

机译：与异柠檬酸脱氢酶野生型胶质母细胞瘤相比，在异柠檬酸脱氢酶突变的胶质母细胞瘤中发现的侵袭性表型更少：扩散张量成像研究

Prediction of Core Signaling Pathway by Using Diffusion-and Perfusion-based MRI Radiomics and Next-generation Sequencing in Isocitrate Dehydrogenase Wild-type Glioblastoma

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