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Evaluation of a combined emulsion process to encapsulate methylene blue into PLGA nanoparticles

机译：将乳液法的评价将亚甲基蓝包埋到PLGA纳米粒子中

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摘要

The delivery of photosensitizer compounds using biodegradable nanoparticles could improve dosage, controlled release and its bioavailability. In this study, methylene blue (MB) loaded PLGA nanoparticles (MB-PNP) are prepared by a new approach combining single and double emulsification techniques. Comparisons of MB-PNP obtained with the combined and the individual techniques are presented. Nanoparticles are characterized by dynamic light scattering, laser Doppler electrophoresis and scanning electron microscopy. Particles prepared by the combined technique presented hydrodynamic diameters of 186 nm. The sizes of MB-PNP obtained from the single emulsion technique are similar to the combined technique, while the diameter of particles prepared by double emulsion increased from 201 nm to 287 nm as the TDL increased. MB-PNP displayed an average zeta potential between -21 mV and -28 mV for all formulations. MB loading ranges between 0.3-1.4%, while the encapsulation efficiency ranges from 8-14%, both depending on the TDL and the preparation technique. In vitro release studies show a monophasic release profile that was analyzed by considering the mechanisms of initial burst, drug diffusion and a combination of them. Experimental results could be better described using a mathematical model of release that simultaneously combines the mechanisms of initial burst and drug diffusion. The approach presented to encapsulate MB and also to analyze the drug release could be extended to other drugs with partial solubility.
机译：使用可生物降解的纳米颗粒的光敏剂化合物的递送可以改善剂量，控制释放及其生物利用度。在该研究中，通过组合单一和双乳化技术的新方法制备亚甲基蓝（MB）的PLGA纳米颗粒（MB-PNP）。提出了用组合和各个技术获得的MB-PNP的比较。纳米颗粒的特征在于动态光散射，激光多普勒电泳和扫描电子显微镜。通过组合技术制备的颗粒呈现186nm的流体动力直径。从单乳液技术获得的MB-PNP的尺寸类似于组合技术，而通过双乳液制备的颗粒的直径从201nmM至287nm增加，因为TDL增加。 MB-PNP在所有制剂中显示出-21mV和-28 mV之间的平均Zeta电位。 MB加载范围在0.3-1.4％之间，而封装效率范围为8-14％，两者均取决于TDL和制备技术。体外释放研究表明，通过考虑初始爆发，药物扩散和它们的组合来分析单表释放曲线。使用释放的数学模型可以更好地描述实验结果，同时结合初始爆发和药物扩散的机制。呈现用于包封MB的方法以及分析药物释放的方法可以扩展到具有部分溶解度的其他药物。

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