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首页> 外文期刊>RSC Advances >Biomimetic cellulose/calcium-deficient-hydroxyapatite composite scaffolds fabricated using an electric field for bone tissue engineering
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Biomimetic cellulose/calcium-deficient-hydroxyapatite composite scaffolds fabricated using an electric field for bone tissue engineering

机译：使用电场为骨组织工程制造的仿生纤维素/钙缺乏羟基磷灰石复合支架

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摘要

Cellulose has been widely used as micro/nanofibers in various applications of tissue regeneration, but has certain limitations for bone regeneration, e.g., low biocompatibility in inducing osteogenesis. In addition, the low processability from the decomposition property before melting can be a significant obstacle to fabricating a required complex structure through a 3D-printing process. Herein, to overcome the low osteogenic activity of pure cellulose, we suggest a new cellulose-based composite scaffold consisting of cellulose and a high weight fraction (70 wt%) of calcium-deficient-hydroxyapatite (CDHA), which was obtained from the hydrolysis of -tricalcium phosphate. Using biocompatible components, we fabricated a 3D pore-structure controllable composite scaffold consisting of microfibrous bundles through an electrohydrodynamic printing (EHDP) process supplemented with an ethanol bath. To obtain a mechanically stable and repeatable 3D mesh structure, various process parameters (nozzle-to-target distance, electric field strength, flow rate, and nozzle moving speed) were considered. As a control, a mesh structure fabricated using a normal EHDP process and with a similar pore geometry was used. A variety of cellular responses using preosteoblasts (MC3T3-E1) indicate that a CDHA/cellulose composite scaffold provides an efficient platform for inducing significantly high bone mineralization.
机译：在组织再生的各种应用中，纤维素已被广泛用作微/纳米纤维，但对骨再生具有一定的限制，例如诱导骨肉发生的低生物相容性。此外，在熔化之前的分解性能的低可加工性可以是通过3D印刷过程制造所需复合结构的重要障碍。在此，为了克服纯纤维素的低骨质发生活性，我们建议由纤维素和高重量级分（70wt％）的钙缺乏磷灰石（CDHA）组成的新的纤维素基复合支架，其从水解中获得磷酸钙。使用生物相容性组分，我们制造了一种由微纤维束组成的3D孔隙结构可控复合支架，通过补充有乙醇浴的电液动力学印刷（EHDP）。为了获得机械稳定和可重复的3D网状结构，考虑了各种工艺参数（喷嘴到目标距离，电场强度，流速和喷嘴移动速度）。作为一种控制，使用使用正常EHDP工艺制造的网状结构并具有类似的孔隙几何形状。使用预卵细胞（MC3T3-E1）的各种细胞反应表明CDHA /纤维素复合支架提供了一种有效的平台，用于诱导显着高的骨矿化。

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  • 来源
    《RSC Advances》 |2018年第37期|共11页
  • 作者

    Kim MyoJin; Yeo MiJi; Kim Minseong; Kim GeunHyung;

  • 作者单位

    Sungkyunkwan Univ SKKU Coll Biotechnol &

    Bioengn Dept Biomechatron Engn Suwon South Korea;

    Sungkyunkwan Univ SKKU Coll Biotechnol &

    Bioengn Dept Biomechatron Engn Suwon South Korea;

    Sungkyunkwan Univ SKKU Coll Biotechnol &

    Bioengn Dept Biomechatron Engn Suwon South Korea;

    Sungkyunkwan Univ SKKU Coll Biotechnol &

    Bioengn Dept Biomechatron Engn Suwon South Korea;

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  • 正文语种 eng
  • 中图分类 化学;
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