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Plasmono-magnetic material for precise photothermal heating

机译：用于精确的光热加热的偏移磁性材料

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摘要

Noble metal nanoparticles have been extensively studied as photo-sensitive agents for photothermal cancer therapy. Precise control over the size and shape of the nanoparticles allowed strong optical absorption and efficient heat generation necessary for destroying a tumor to be achieved. However, one of the fundamental challenges of application of the nanoparticles towards photothermal cancer therapy is low specificity in the targeting tumor tissue in comparison with the healthy tissue and the resulting unfavorable biodistribution of the nanoparticles. Additional levels of control over particle distribution can be achieved by making the particles magnetic and using external magnets to control their accumulation in a tumor. Since the direct synthesis of particles with a magnetic core and a metallic shell limits the options for design and fine-tuning of plasmonic properties, the alternative approaches to the design of such materials have to be investigated. Here we propose and demonstrate a new design of a hybrid plasmono-magnetic material for photothermal heating created by grafting Au nanocages onto a surface of magnetic micro-beads. Next, we confirm its dual functionality in in vitro studies and show that individual hybrid particles can be magnetically controlled with a precision of a few micrometers and precisely destroy individual cells using plasmonic heating.
机译：已经广泛地研究了贵金属纳米颗粒作为光热癌疗法的光敏剂。对纳米颗粒的尺寸和形状进行精确控制允许破坏肿瘤所需的强光吸收和有效的发热。然而，与健康组织相比，靶向肿瘤组织中，纳米颗粒的应用朝向光热癌治疗的一个根本挑战是靶向肿瘤组织的特异性，并导致纳米颗粒的不利生物分布。通过使颗粒磁性和使用外部磁体来控制其在肿瘤中的积累来实现对颗粒分布的额外控制水平。由于具有磁芯和金属壳的颗粒的直接合成限制了等离子体性能的设计和微调的选择，因此必须研究这些材料设计的替代方法。在这里，我们提出并证明了一种用于通过将Au nancage接种到磁性微珠表面上的光热加热的混合偏移磁性材料的新设计。接下来，我们在体外研究中确认其双重功能，并表明各个杂种颗粒可以用几微米的精度磁控地控制，并且使用等离子体加热精确地破坏各个细胞。

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  • 来源
    《RSC Advances》 |2018年第5期|共7页
  • 作者

    Ladanov Mikhail; Cheemalapati Surya; Wang Hao; Yuan Yuan; Koria Piyush; Pyayt Anna;

  • 作者单位

    Univ S Florida Dept Chem &

    Biomed Engn Tampa FL 33647 USA;

    Univ S Florida Dept Chem &

    Biomed Engn Tampa FL 33647 USA;

    Univ S Florida Dept Chem &

    Biomed Engn Tampa FL 33647 USA;

    Univ S Florida Dept Chem &

    Biomed Engn Tampa FL 33647 USA;

    Univ S Florida Dept Chem &

    Biomed Engn Tampa FL 33647 USA;

    Univ S Florida Dept Chem &

    Biomed Engn Tampa FL 33647 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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