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首页> 外文期刊>RSC Advances >Janus N,N-dimethylformamide as a solvent for a gradient porous wound dressing of poly(vinylidene fluoride) and as a reducer for in situ nano-silver production: anti-permeation, antibacterial and antifouling activities against multi-drug-resistant bacteria both in vitro and in vivo
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Janus N,N-dimethylformamide as a solvent for a gradient porous wound dressing of poly(vinylidene fluoride) and as a reducer for in situ nano-silver production: anti-permeation, antibacterial and antifouling activities against multi-drug-resistant bacteria both in vitro and in vivo

机译：Janus N，N-二甲基甲酰胺作为聚（偏二氟乙烯）的梯度多孔伤口敷料的溶剂，作为原位纳米银产量的减速器：抗渗透，抗渗透，抗菌和防污活动，无论是多种耐药细菌 体外和体内

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摘要

The requirements for anti-permeation, anti-infection and antifouling when treating a malicious wound bed raise new challenges for wound dressing. The present study used N,N-dimethylformamide to treat poly(vinylidene fluoride) (PVDF) in order to obtain a dressing impregnated with in situ generated nano-silver particles (NS) via an immersion phase inversion method. Scanning electron microscopy (SEM) images showed that the film was characterized by a two-layer asymmetric structure with different pore sizes (top layer: similar to 0.4 mu m; bottom layer: similar to 1.8 mu m). The moisture permeability test indicated that the film had an optimal water vapor transmission rate (WVTR: similar to 2500 g m(-2) per day). TEM images revealed the successful formation of spherical NS, and Fourier-transform infrared spectroscopy (FTIR) demonstrated the integration of PVDF and NS (i.e., PVDF/NS). Correspondingly, the water contact angle measurements confirmed increased membrane surface hydrophobicity after NS integration. The inductively coupled plasma (ICP) spectrometry showed that the PVDF/NS displayed a continuous and safe release of silver ions. Moreover, in vitro experiments indicated that PVDF/NS films possessed satisfactory anti-permeation, antibacterial and antifouling activities against A. baumannii and E. coli bacteria, while they exhibited no obvious cytotoxicity toward mammalian HaCaT cells. Finally, the in vivo results showed that the nanoporous top layer of film could serve as a physical barrier to prevent bacterial penetration, whereas the microporous bottom layer could efficiently prevent bacterial infection caused by biofouling, leading to fast re-epithelialization via the enhancement of keratinocyte proliferation. Collectively, the results show that the PVDF/NS25 film has a promising application in wound treatment, especially for wounds infected by multi-drug-resistant bacteria such as A. baumannii.
机译：治疗恶意伤口床时抗渗透，抗感染和防污的要求提高了伤口敷料的新挑战。本研究使用N，N-二甲基甲酰胺处理聚（偏二氟乙烯）（PVDF），以通过浸渍相反转方法获得浸渍有原位产生的纳米银颗粒（NS）的敷料。扫描电子显微镜（SEM）图像显示，薄膜的特征在于具有不同孔径的双层不对称结构（顶层：类似于0.4μm;底层：类似于1.8 mu m）。透湿性试验表明，薄膜具有最佳的水蒸气透射率（WVTR：与每天2500g m（-2）相似）。 TEM图像揭示了球形NS的成功形成，傅立叶变换红外光谱（FTIR）证明了PVDF和NS（即，PVDF / NS）的积分。相应地，在NS集成后，水接触角测量结果证实了膜表面疏水性增加。电感耦合等离子体（ICP）光谱法显示PVDF / NS显示出银离子的连续和安全释放。此外，体外实验表明，PVDF / NS薄膜对A.Baumannii和大肠杆菌细菌具有令人满意的抗渗透，抗菌和防污活动，而它们对哺乳动物HaCAT细胞没有明显的细胞毒性。最后，体内结果表明，纳米多孔顶层薄膜可以用作防止细菌渗透的物理屏障，而微孔底层可以有效地预防由生物污染引起的细菌感染，导致通过角质形成细胞的增强来快速重新上皮。增殖。总的来说，结果表明，PVDF / NS25薄膜在伤口治疗中具有有希望的应用，特别是对于被多种耐药细菌感染的伤口，例如A.Baumannii。

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  • 来源
    《RSC Advances》 |2018年第47期|共14页
  • 作者

    Liu Menglong; Wang Ying; Hu Xiaodong; He Weifeng; Gong Yali; Hu Xiaohong; Liu Meixi; Luo Gaoxing; Xing Malcolm; Wu Jun;

  • 作者单位

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Sichuan Univ State Key Lab Polymer Mat Engn Polymer Res Inst Chengdu 610065 Sichuan Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

    Army Med Univ State Key Lab Trauma Burn &

    Combined Injury Third Mil Med Univ Inst Burn Res Southwest Hosp Chongqing 400038 Peoples R China;

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