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首页> 外文期刊>RSC Advances >Stratum corneum lipid liposomes for investigating skin penetration enhancer effects
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Stratum corneum lipid liposomes for investigating skin penetration enhancer effects

机译：Stratum Corneum脂质脂质体，用于研究皮肤渗透性增强剂效应

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摘要

Knowledge of the mechanism of action of skin penetration enhancers is essential to formulators for optimizing formulations and to maximize the efficacy of enhancers. To obtain information about the effects of penetration enhancers as a fast initial screening, investigations have been performed to identify possible correlations of the biological effectiveness of penetration enhancers with their interaction with a well-defined model system consisting of skin mimic lipid bilayers, as determined by calcein release experiments using stratum corneum lipid liposomes (SCLLs). We aimed to investigate the enhancing effects of different concentrations of two chemical penetration enhancers, Kolliphor RH40 and Transcutol on SCLLs. The results obtained by SCLL-based techniques were compared with conventional ex vivo penetration studies in case of Kolliphor RH40 to evaluate the potential of SCLLs as an alternative tool for screening various types and concentrations of penetration enhancers. As a result, calcein leakage assay performed with SCLL was considered to be a good model for the skin penetration enhancing effect. This method could be used as a time-saving and sensitive alternative in vitro screening technique in the early stage of the development of dermal formulations.
机译：知识皮肤渗透增强剂的作用机制对于用于优化配方的配方和最大化增强剂的疗效至关重要。为了获得有关渗透增强剂的效果作为快速初始筛查的信息，已经进行了研究以确定渗透增强剂的生物效力与其与由皮肤模拟脂质双层组成的明确定义模型系统的相互作用的可能相关性，如图所示Calcein释放使用Stratum Cyneum脂质脂质体（SCLL）的实验。我们的旨在探讨不同浓度的两种化学渗透增强剂，Kolliphor RH40和超扫描对Sclls的增强效果。将基于SCLL的技术获得的结果与Kolliphor RH40的常规离体渗透研究进行了比较，以评估SCLLS作为替代工具的潜在工具，用于筛选各种类型和浓度的渗透增强剂。结果，用SCLL进行的Calcein泄漏测定被认为是皮肤渗透性增强效果的良好模型。该方法可以用作高层制剂发育早期阶段的节省且敏感的替代方案。

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  • 来源
    《RSC Advances》 |2018年第48期|共6页
  • 作者

    Bakonyi Monika; Gacsi Attila; Berko Szilvia; Kovacs Anita; Csanyi Erzsebet;

  • 作者单位

    Univ Szeged Inst Pharmaceut Technol &

    Regulatory Affairs H-6720 Szeged Hungary;

    Univ Szeged Inst Pharmaceut Technol &

    Regulatory Affairs H-6720 Szeged Hungary;

    Univ Szeged Inst Pharmaceut Technol &

    Regulatory Affairs H-6720 Szeged Hungary;

    Univ Szeged Inst Pharmaceut Technol &

    Regulatory Affairs H-6720 Szeged Hungary;

    Univ Szeged Inst Pharmaceut Technol &

    Regulatory Affairs H-6720 Szeged Hungary;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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