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Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

机译：用于疏水药物递送的自组装pH-响应超分子水凝胶

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摘要

In this study, a novel supramolecular hydrogel system, abbreviated as AGC(16)/NTS, prepared by molecular self-assembly of cationic gemini surfactant 1,3-bis(N,N-dimethyl-N-cetylammonium)-2-propylacrylatedibromide (AGC(16)) and anionic aromatic compound trisodium 1,3,6-naphthalenetrisulfonate (NTS), was used to encapsulate hydrophobic model drug curcumin (Cur), constructing a pH-responsive drug delivery system. Cur was effectively encapsulated into the hydrophobic domains of AGC(16)/NTS through hydrophobic interaction, which was confirmed by H-1 NMR measurement. The effects of Cur on the mechanical strength, phase transition behaviour and morphology of AGC(16)/NTS were characterized by rheology and cryogenic scanning electron microscopy (cryo-SEM) methods. The pH-responsive release of Cur from AGC(16)/NTS was obtained and the release amount of Cur ascended with pH value decreasing from 7.4 to 3.0. The hydrodynamic sizes of the released Cur-aggregates determined by dynamic light scattering (DLS) were used to analyse the release process of Cur at different pH. The cell viability assay and cell imaging experiment demonstrated that Cur-loaded hydrogel has much higher cytotoxicity and better cell uptake compared to free Cur. Overall, the AGC(16)/NTS hydrogel is a prospective material for use in encapsulation and controlled-release of hydrophobic drug molecules.
机译：在该研究中，一种新的超分子水凝胶系统，缩写为AGC（16）/ NTS，通过阳离子双子粒子表面活性剂1,3-双（N，N-二甲基-N-十六烷基铵）-2-丙烯酸纤维氧化物（ AGC（16））和阴离子芳族化合物三钠1,3,6-萘四硫酸钠（NTS）用于包封疏水模型药物姜黄素（CUR），构建pH-响应药物输送系统。通过疏水相互作用有效地包封在AGC（16）/ NTS的疏水结构域中，通过H-1 NMR测量证实。通过流变和低温扫描电子显微镜（Cryo-SEM）方法表征了Cur对AGC（16）/ NTS的机械强度，相转移行为和形态的影响。获得来自AGC（16）/ NTS的Cur的pH-响应释放，并且释放的CH值升高的pH值从7.4-3.0降低。通过动态光散射（DLS）确定的释放的Cur聚集体的流体动力学尺寸用于分析不同pH的Cur的释放过程。细胞活力测定和细胞成像实验表明，与游离Cur相比，加载的水凝胶具有更高的细胞毒性和更好的细胞吸收。总的来说，AGC（16）/ NTS水凝胶是用于封装和控制疏水药物分子的封装和控制释放的前瞻性材料。

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  • 来源
    《RSC Advances》 |2018年第55期|共7页
  • 作者

    Wang Lin; Shi Xuefeng; Zhang Jian; Zhu Yuejun; Wang Jinben;

  • 作者单位

    Chinese Acad Sci Inst Chem CAS Key Lab Colloid Interface &

    Chem Thermodynam Beijing 100190 Peoples R China;

    Chinese Acad Sci Inst Chem CAS Key Lab Colloid Interface &

    Chem Thermodynam Beijing 100190 Peoples R China;

    CNOOC Res Inst Co Ltd State Key Lab Offshore Oil Exploitat Beijing 100028 Peoples R China;

    CNOOC Res Inst Co Ltd State Key Lab Offshore Oil Exploitat Beijing 100028 Peoples R China;

    Chinese Acad Sci Inst Chem CAS Key Lab Colloid Interface &

    Chem Thermodynam Beijing 100190 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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