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Bio-distribution and bio-availability of silver and gold in rat tissues with silver/gold nanorod administration

机译：用银/金纳米棒给药大鼠组织中银和金的生物分布和生物可用性

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摘要

Along with the increasing applications of nanomaterials in medical fields, to know the systemic distribution of nanomaterials in the body through a precise method is required for the biosafety assessment of nanomaterials. In this study, we firstly have established a reliable inductively coupled plasma mass spectrometry (ICP-MS) method for concentration measurement of silver (Ag) and gold (Au) in biological tissues. Then, based on this method, the Ag or Au distribution in rat blood and almost all of the organs were analyzed after an i.v. or s.c. administration of Au@Ag NRs. Both the time-dependent contents of Ag and Au in blood and two pharmacokinetic models confirmed the rapid clearance of Ag from blood. At 24 h after i.v. injection, there was the highest level of Ag in liver, followed by portal nodes, spleen, lung, bone marrow and pancreas. In addition, we also found there were gender-related distributions of Ag and Au in some organs, especially after s.c. injection. Therefore, these more comprehensive and important results would give fundamental information for the biological risk assessment of nanomaterials.
机译：随着纳米材料在医疗领域的增加以及纳米材料的生物安全评估需要通过精确方法了解体内纳米材料的全身分布。在这项研究中，我们首先建立了可靠的电感耦合等离子体质谱（ICP-MS）方法，用于生物组织中的银（Ag）和金（Au）的浓度测量。然后，基于该方法，在I.V之后分析了大鼠血液和几乎所有器官的AG或Au分布。或s.c.。管理AU @ AG NRS。血液和两种药代动力学模型中Ag和Au的时间依赖性含量证实了血液的快速清除。在I.v后24小时。注射，肝脏中有最高水平的AG，其次是门户节点，脾脏，肺，骨髓和胰腺。此外，我们还发现在某些器官中有与AG和Au的性别相关的分布，特别是在S.C之后。注射。因此，这些更全面和重要的结果将为纳米材料的生物风险评估提供基本信息。

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  • 来源
    《RSC Advances》 |2018年第22期|共9页
  • 作者

    Wu Meiyu; Chen Liang; Li Ruiru; Dan Mo; Liu Haining; Wang Xinsheng; Wu Xiaochun; Liu Ying; Xu Liming; Xie Liming;

  • 作者单位

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Standardizat &

    Measurement Nanotechno 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

    Natl Inst Food &

    Drug Control NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom Inst Med Devices Control Biol Med Ind Base 31 Huatuo Rd Beijing 102629 Peoples R China;

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Standardizat &

    Measurement Nanotechno 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

    Natl Inst Food &

    Drug Control NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom Natl Ctr Safety Evaluat Drugs 8 Hongda Mid Rd Beijing 100176 Peoples R China;

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Standardizat &

    Measurement Nanotechno 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Standardizat &

    Measurement Nanotechno 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Standardizat &

    Measurement Nanotechno 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Biomed Effects Nanomat &

    Nanosafety 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

    Natl Inst Food &

    Drug Control NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom Inst Med Devices Control Biol Med Ind Base 31 Huatuo Rd Beijing 102629 Peoples R China;

    Natl Ctr Nanosci &

    Technol Ctr Excellence Nanosci NCNST NIFDC Joint Lab Measurement &

    Evaluat Nanom CAS Key Lab Standardizat &

    Measurement Nanotechno 11 Beiyitiao Zhongguancun Beijing 100190 Peoples R China;

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