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首页> 外文期刊>RSC Advances >Metabolism of five diterpenoid lactones from Dioscorea bulbifera tubers in zebrafish
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Metabolism of five diterpenoid lactones from Dioscorea bulbifera tubers in zebrafish

机译：来自Dioscorea Bulbifera块茎的五种二萜内酯的代谢Zebrafish

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摘要

Diterpenoid lactones (DLs) have been reported to be themain hepatotoxic constituents in Dioscorea bulbifera tubers (DBT), a traditional Chinese medicinal herb. The acquisition of early information regarding its metabolism is critical for evaluating the potential hepatotoxicity of DLs. We investigated, for the first time, the main metabolites of diosbulbin A (DIOA), diosbulbin C (DIOC), diosbulbin (DIOG), diosbulbin (DIOM) and diosbulbin (DIOF) in adult zebrafish. By using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS), 6, 2, 7, 5 and 4 metabolites of DIOA, DIOC, DIOF, DIOM and DIOG were identified in the zebrafish body and the aqueous solution, respectively. Both phase-I and phase-II metabolites were observed in the metabolic profiles and the metabolic pathways involved in hydroxyl reduction, glucuronidation, glutathione conjugation and sulfation. The above results indicated that hepatocytic metabolism might be the major route of clearance for DLs. This study provided important information for the understanding of the metabolism of DLs in DBT.
机译：据报道，二萜类乳酸酯（DLS）是在Dioscorea Bulbifera块茎（DBT）中的肝毒性成分，是一种中药草药。收购关于其新陈代谢的早期信息对于评估DLS的潜在肝毒性至关重要。我们首次调查了DioSbulbin A（DIOA），二磷脂C（DIOC），Diosbulbin（DioG），DioSbulbin（Diom）和Diosbulbin（Diof）的主要代谢物。通过使用超高效液相色谱 - 四极杆飞行时间质谱（UHPLC-QTOF MS），6,2,7,5和4代谢物，DIOA，DIOC，DIOF，DIOM和DIOG在斑马鱼体内鉴定出来和水溶液。在代谢谱中观察到相I和相II代谢物和参与羟基降低，葡糖醛，谷胱甘肽缀合和硫酸的代谢途径。上述结果表明，肝细胞代谢可能是DLS的主要间隙途径。本研究提供了理解DBT中DLS新陈代谢的重要信息。

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  • 来源
    《RSC Advances》 |2018年第14期|共9页
  • 作者

    Shi Wei; Ling Jie; Jiang Li-Long; Zhao Dong-Sheng; Wang Ling-Li; Wu Zi-Tian; Li Ping; Wei Ying-Jie; Li Hui-Jun;

  • 作者单位

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Clin Sch Med 3 100 Shizi St Nanjing 210028 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Clin Sch Med 3 100 Shizi St Nanjing 210028 Jiangsu Peoples R China;

    China Pharmaceut Univ State Key Lab Nat Med 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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