Targeting HMGA protein inhibits retinoblastoma cell proliferation

Balachandran Akilandeswari; Zambre Ajit; Kainth Jagjot Singh; Selvan Lakshmi Dhevi Nagarajha; Parameswaran Sowmya; Afrasiabi Zahra; Krishnakumar Subramanian; Kannan Raghuraman; Upendran Anandhi

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Targeting HMGA protein inhibits retinoblastoma cell proliferation

机译：靶向HMGA蛋白抑制视网膜细胞瘤细胞增殖

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We describe a novel synthetic strategy for conjugating HMGA2 siRNA and the HMGA aptamer to the nucleolin aptamer and nucleolin antibody, respectively. Our studies demonstrate that these conjugates inhibit cell proliferation in retinoblastoma cells.

机译：我们描述了一种用于将HMGA2 siRNA和HMGA适体缀合到核仁适体和核仁抗体的新型合成策略。我们的研究表明，这些缀合物抑制了视网膜细胞瘤细胞中细胞增殖。

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来源
《RSC Advances》 |2018年第55期|共5页
作者
Balachandran Akilandeswari; Zambre Ajit; Kainth Jagjot Singh; Selvan Lakshmi Dhevi Nagarajha; Parameswaran Sowmya; Afrasiabi Zahra; Krishnakumar Subramanian; Kannan Raghuraman; Upendran Anandhi;
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作者单位

Kamalnayan Bajaj Inst Res Vis &

Ophthalmol Vis Res Fdn Dept Nanobiotechnol Madras Tamil Nadu India;

Univ Missouri Dept Radiol Columbia MO 65211 USA;

Univ Missouri Dept Radiol Columbia MO 65211 USA;

Kamalnayan Bajaj Inst Res Vis &

Ophthalmol Vis Res Fdn L&

T Ocular Pathol Dept Madras Tamil Nadu India;

Kamalnayan Bajaj Inst Res Vis &

Ophthalmol Vis Res Fdn Radheshyam Kanoi Stem Cell Lab Madras Tamil Nadu India;

Lincoln Univ Dept Life Sci Jefferson City MO USA;

Kamalnayan Bajaj Inst Res Vis &

Ophthalmol Vis Res Fdn Dept Nanobiotechnol Madras Tamil Nadu India;

Univ Missouri Dept Radiol Columbia MO 65211 USA;

Univ Missouri Dept Med Pharmacol &

Physiol Columbia MO 65211 USA;

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正文语种 eng
中图分类化学;
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1. Targeting HMGA protein inhibits retinoblastoma cell proliferation [J] . Balachandran Akilandeswari, Zambre Ajit, Kainth Jagjot Singh, RSC Advances . 2018,第55期

机译：靶向HMGA蛋白抑制视网膜细胞瘤细胞增殖
2. High mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest. [J] . Ueda Y, Watanabe S, Tei S, Cancer science. . 2007,第12期

机译：高迁移率族蛋白HMGA1抑制成视网膜细胞瘤蛋白介导的细胞G0阻滞。
3. MicroRNA-320 inhibits cell proliferation, migration and invasion in retinoblastoma by targeting specificity protein 1 [J] . Zhao Yuehua, Zhang Shilian, Zhang Yongfeng Molecular medicine reports . 2017,第2aPta2期

机译：通过靶向特异性蛋白1，MicroRNA-320抑制视网膜细胞瘤中的细胞增殖，迁移和侵袭
4. Oxythiaminespecifically inhibits heat shock protein 27 (Hsp27) phosphorylationand cell proliferation in MIA pancreatic cancer cells [C] . Cetner RuiCao, Hengwei Zhang, Wai-Nang Paul Lee, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：羟基氨基纤维素抑制MIA胰腺癌细胞中的热休克蛋白27（HSP27）磷酸化和细胞增殖
5. Targeting the Activator Protein-1 Complex to Inhibit Airway Smooth Muscle Cell Hyperproliferation in Asthma [D] . Defnet, Amy Elizabeth. 2021

机译：靶向活化剂蛋白-1复合物，以抑制哮喘中的气道平滑肌细胞过度增殖
6. let-7i inhibits proliferation and migration of bladder cancer cells by targeting HMGA1 [O] . M-M Qin, X. Chai, H-B Huang, 2019

机译：let-7i通过靶向HMGA1抑制膀胱癌细胞的增殖和迁移
7. Targeting HMGA protein inhibits retinoblastoma cell proliferation [O] . Akilandeswari Balachandran, Ajit Zambre, Jagjot Singh Kainth, 2018

机译：靶向HMGA蛋白抑制视网膜细胞瘤细胞增殖

Targeting HMGA protein inhibits retinoblastoma cell proliferation

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