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Effects of pore size on in vitro and in vivo anticancer efficacies of mesoporous silica nanoparticles

机译：孔径对体外和体内抗癌性介孔二氧化硅纳米粒子的影响

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摘要

Mesoporous silica nanoparticles (MSN) have been widely applied for drug delivery systems. To investigate the effects of pore size on anticancer efficacies, MSN with different pore sizes but similar particle sizes and surface charges were synthesized via a microemulsion method. The pore structures of MSN were characterized by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), and N-2 adsorption-desorption isotherms. Doxorubicin loaded MSN (DOX/MSN) were prepared and the minimum drug loading capacity was detected in DOX/MSN with a pore size of 2.3 nm (DOX/MSN2). DOX/MSN with a pore size of 8.2 nm (DOX/MSN8) showed a comparable drug loading amount in comparison with ones with a pore size of 5.4 nm (DOX/MSN5). In vitro drug release profiles showed that DOX/MSN5 could release DOX quickly and completely. Compared with DOX/MSN2 and DOX/MSN8, DOX/MSN5 showed the higher cellular uptake and nucleic concentration of DOX in QGY-7703 cells, which led to efficient cell-apoptosis induction and anti-proliferation effect, and thus the optimal in vivo anticancer activities. Taken together, these results highlighted the importance of pore size in anticancer efficacies, which would serve as a guideline in the rational design of MSN for cancer therapy.
机译：中孔二氧化硅纳米颗粒（MSN）已广泛应用于药物递送系统。为了探讨孔径对抗癌效率的影响，通过微乳液法合成了具有不同孔径但相似粒度和表面电荷的MSN。通过透射电子显微镜（TEM），小角X射线散射（SAX）和N-2吸附 - 解吸等温线的孔结构表征。制备了多柔比星的MSN（DOX / MSN），在DOX / MSN中检测到最小药物负载能力，孔径为2.3nm（DOX / MSN2）。具有8.2nm（Dox / MSN8）的孔径为8.2nm（Dox / MSN8）的Dox / MSN显示了与孔径为5.4nm（dox / msn5）的药物加载量。体外药物释放曲线显示，DOX / MSN5可以快速且完全释放DOX。与DOX / MSN2和DOX / MSN8相比，DOX / MSN5在QGY-7703细胞中显示了DOX的较高的细胞摄取和核浓度，从而有效的细胞凋亡诱导和抗增殖效应，因此在体内抗癌的最佳效应活动。总之，这些结果突出了孔径在抗癌效率中的重要性，这将作为癌症治疗MSN合理设计的指导。

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  • 来源
    《RSC Advances》 |2018年第43期|共8页
  • 作者

    Li Jie; Shen Suqin; Kong Fei; Jiang Ting; Tang Cui; Yin Chunhua;

  • 作者单位

    Fudan Univ Sch Life Sci Shanghai 200438 Peoples R China;

    Fudan Univ Sch Life Sci Shanghai 200438 Peoples R China;

    Fudan Univ Sch Life Sci Shanghai 200438 Peoples R China;

    Fudan Univ Sch Life Sci Shanghai 200438 Peoples R China;

    Fudan Univ Sch Life Sci Shanghai 200438 Peoples R China;

    Fudan Univ Sch Life Sci Shanghai 200438 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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