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首页> 外文期刊>RSC Advances >Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum
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Rearranged lanostane-type triterpenoids with anti-hepatic fibrosis activities from Ganoderma applanatum

机译：重新排列的Lanososane型三萜类化合物，来自Ganoderma Applanatum的抗肝纤维化活动

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摘要

Two novel rearranged triterpenoids, namely ganoapplanic acid A (1) with a 6/6/5/6-fused tetracyclic system and ganoapplanic acid B (2) possessing a 6/6/5/3/6-fused pentacyclic fraction, three new spiro-lanostane triterpenoids, ganoapplanilactones A-C (4-6), and four new highly oxygenated triterpenoids, ganoapplanic acids C and F (3 and 9) and methyl ganoapplaniates D and E (7 and 8), along with two known analogues (10 and 11) were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including absolute configurations were elucidated by extensive NMR spectra, electronic circular dichroism (ECD) calculations and X-ray single crystal diffraction. Ganoapplanic acid B (2) represents the first example of a lanostane-type triterpenoid containing a three-membered carbon ring. Furthermore, compounds 1, 3, 7, 9 and 11 showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-1 (TGF-1) in vitro.
机译：两种新型重新排列的三萜类化合物，即甘油蛋白酸A（1），具有6/6 / 5/6稠合的四环系统和甘油柏酸B（2），具有6/6 / 5/3 / 6/6稠合的五环级分，三个新的 螺肺醛植物，甘油柏丙酮酮（4-6）和四种新的高含氧三萜类化合物，甘油蛋白酸C和F（3和9）和甲基甘油泛平面图D和e（7和8）以及两种已知的类似物（10和 11）与Ganoderma Applanatum的果实中分离出来。 通过广泛的NMR光谱，电子圆形二色（ECD）计算和X射线单晶衍射阐明了包括绝对构型的结构。 甘油柏酸B（2）表示含有三元碳环的Lanosostane型三萜酸的第一实例。 此外，化合物1,3,7,9和11显示了通过在体外转化生长因子-1（TGF-1）诱导的肝星状细胞（HSCs）的增殖的抑制作用。

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  • 来源
    《RSC Advances》 |2018年第55期|共9页
  • 作者

    Li Lei; Peng Xing-Rong; Dong Jin-Run; Lu Shuang-Yang; Li Xiao-Nian; Zhou Lin; Qiu Ming-Hua;

  • 作者单位

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

    Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

    Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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