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Bacteria killing in ICU associated infections: antibacterial nanosheets as disinfectant

机译：在ICU相关感染中的细菌杀死：抗菌纳米片作为消毒剂

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Here we report hybrid antibacterial nanosheets (Zn-CuO@GO) where graphene oxide (GO) is decorated with zinc-doped copper dioxide (Zn-CuO) nanoparticles and applied as disinfectant agents to combat multidrug resistant bacterial strains from intensive care units (ICUs). The difference between different Zn-CuO decoration ratios was carefully evaluated and the results indicated when Zn-CuO was deposited onto GO at 4 : 1 weight ratio (w/w), the obtained Zn-CuO@GO exhibited the best dispersity, which was suitable as an antibacterial supplement for disinfectant. Importantly, the Zn-CuO@GO (4 : 1, w/w) based disinfectant could actively kill 100.0% multidrug bacteria strains within 10 min, including multidrug resistant (MDR) E. coli and methicillin resistant S. aureus (MRSA). Moreover, we measured the antibacterial activities of Zn-CuO@GO at other decoration ratios (i.e., 2 : 1 and 1 : 1, w/w) to study the effect of Zn-CuO decoration density on the antibiosis activity of Zn-CuO@GO. It was also found that decreased Zn-CuO deposition density not only caused the agglomerateion of Zn-CuO@GO nanosheets (largely due to the relatively increased GO ratio), but also extended their required function time to 30 min for complete bacterial killing. Taking Zn-CuO@GO (4 : 1, w/w) as the optimized antibacterial nanosheet, further TEM, SEM ad LCSM images revealed that Zn-CuO@GO functions via penetrating and wrapping into the cell wall, inducing bacterial sedimentation and cytoplasma leakage, which make them promising for next-generation disinfectant substitution.
机译：在这里，我们报告杂种抗菌纳米片（Zn-CuO @ Go），其中石墨烯（GO）用锌掺杂铜二氧化铜（Zn-CuO）纳米颗粒装饰，并作为消毒剂从重症监护单元中打击多药物抗菌菌株（ICU ）。仔细评估不同Zn-CuO装饰比之间的差异，并将Zn-CuO沉积在4：1重量比（W / W）上时所示的结果表明，所得Zn-CuO @ Go展现出最好的分散性，即适合作为消毒剂的抗菌补充剂。重要的是，基于Zn-CuO @ Go（4：1，W / W）的消毒剂可以在10分钟内积极杀死100.0％的多药细菌菌株，包括多药物抗性（MDR）大肠杆菌和甲氧西林S.UUREUS（MRSA）。此外，我们测量了Zn-CuO @去其他装饰比（即，2：1和1：1，w / w）的抗菌活性，以研究Zn-Cuo装饰密度对Zn-CuO抗生素活性的影响@走。还发现，降低Zn-CuO沉积密度不仅使得Zn-CuO @ Go anoheets的聚集（主要是由于相对增加的GO比率），而且还将其所需的函数时间延长至30分钟以进行完全的细菌杀伤。服用Zn-CuO @ Go（4：1，W / W）作为优化的抗菌纳米片，进一步的TEM，SEM AD LCSM图像显示，通过穿透和包裹在细胞壁中，诱导细菌沉降和细胞质的Zn-CuO @ Go功能泄漏，这使得它们对下一代消毒剂的替代有望。

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  • 来源
    《RSC Advances》 |2018年第1期|共6页
  • 作者

    Zhang Li; Lou Jiaming; Zhang Wei; Wu Chaoyang; Jin Zhaocheng;

  • 作者单位

    Jiangsu Univ Affiliated Peoples Hosp Dept Crit Care Med Unit Zhenjiang Jiangsu Peoples R China;

    Jiangsu Univ Affiliated Peoples Hosp Dept Emergency Med Zhenjiang Jiangsu Peoples R China;

    Jiangsu Univ Affiliated Peoples Hosp Dept Pain Med Zhenjiang Jiangsu Peoples R China;

    Jiangsu Univ Affiliated Peoples Hosp Dept Oncol Zhenjiang Jiangsu Peoples R China;

    Jiangsu Univ Affiliated Peoples Hosp Dept Crit Care Med Unit Zhenjiang Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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