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首页> 外文期刊>RSC Advances >Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum
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Harzianumnones A and B: two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum

机译：Harziannone A和B：来自珊瑚衍生的真菌ricrichoderma harzianum的两种羟基蒽醌

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摘要

Two new hydroxyanthraquinones, harzianumnones A (1) and B (2), together with seven known analogs (3-9), were isolated from the soft coral-derived fungus Trichoderma harzianum (XS-20090075). Their chemical structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by ECD calculation and single-crystal X-ray diffraction. Compounds 1 and 2 were identified as a pair of epimers, which are the first example of hydroanthraquinones from T. harzianum. Compounds 7 and 8 exhibited cytotoxicity against hepatoma cell line HepG2 with IC50 values of 2.10 and 9.39 mu M, respectively. Compound 7 was still found to show cytotoxicity against cervical cancer cell line HeLa with an IC50 value of 8.59 mu M.
机译：两个新的羟基醌，Harziannone A（1）和B（2）与七种已知的类似物（3-9）分离出从软珊瑚衍生的真菌richoderma harzianum（xs-20090075）中分离出来。 通过广泛的光谱调查阐明了它们的化学结构。 通过ECD计算和单晶X射线衍射确定1和2的绝对配置。 将化合物1和2鉴定为一对基础，这是来自T. harzianum的浓度的第一个实施例。 化合物7和8分别表现出对肝癌细胞系HepG2的细胞毒性，分别具有2.10和9.39μm的IC 50值。 仍然发现化合物7表现出对宫颈癌细胞系HELA的细胞毒性，IC50值为8.59亩。

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  • 来源
    《RSC Advances》 |2018年第49期|共6页
  • 作者

    Shi Ting; Hou Xue-Mei; Li Zhi-Yong; Cao Fei; Zhang Ya-Hui; Yu Jia-Yin; Zhao Dong-Lin; Shao Chang-Lun; Wang Chang-Yun;

  • 作者单位

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

    Shanghai Jiao Tong Univ Sch Life Sci &

    Biotechnol State Key Lab Microbial Metab Marine Biotechnol Lab Shanghai 200240 Peoples R China;

    Hebei Univ Coll Pharmaceut Sci Key Lab Pharmaceut Qual Control Hebei Prov Baoding 071002 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

    Ocean Univ China Sch Med &

    Pharm Minist Educ China Key Lab Marine Drugs Qingdao 266003 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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