A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

Zhou Chun-Qiong; Li Zi-Qi; Liao Ting-Cong; Ma Tian-Zhu; Chen Shuo-Bin; Liang Yuan-Yuan

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A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

机译：一种新颖的平面平面Pt（II）络合物，作为单体和二聚体G-Quadreplex DNA粘合剂

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A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes via end-stacking and external-binding modes.

机译：合成了一种新的菲咪唑乙二胺Pt（II）与香豆素衍生物（1）的络合物合成，并在单体G-四边形（G1）和双相DNA上，对混合型二聚体G-四边形（G2T1）进行更高的亲和力，选择性和热稳定性。复合物1可以通过终端堆叠和外部绑定模式与G-QuadrupleS绑定。

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《RSC Advances》 |2018年第41期|共5页
作者
Zhou Chun-Qiong; Li Zi-Qi; Liao Ting-Cong; Ma Tian-Zhu; Chen Shuo-Bin; Liang Yuan-Yuan;
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Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Guangdong Peoples R China;

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Guangdong Peoples R China;

Sun Yat Sen Univ Sch Pharmaceut Sci Guangzhou 51006 Guangdong Peoples R China;

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515 Guangdong Peoples R China;

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正文语种 eng
中图分类化学;
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1. A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder [J] . Zhou Chun-Qiong, Li Zi-Qi, Liao Ting-Cong, RSC Advances . 2018,第41期

机译：一种新颖的平面平面Pt（II）络合物，作为单体和二聚体G-Quadreplex DNA粘合剂
2. Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity by Square-Planar Nickel(II) Complexes [J] . Julie E.Reed, Anna Arola Arnal, Stephen Neidle, Journal of the American Chemical Society . 2006,第18期

机译：G-四链体DNA的稳定和端平面镍（II）配合物抑制端粒酶活性。
3. Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders [J] . Castor Katherine J., Metera Kimberly L., Tefashe Ushula M., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2015,第14期

机译：环金属化铱（III）咪唑菲咯啉配合物作为发光和电化学发光的G四联体DNA结合剂
4. Influence of Exciplex formation on the electroluminescent properties of dimeric Zn (II) bis‐2‐(2'‐hydroxyphenyl) benzoxazole complex and monomeric Zn (II) 2‐(1'‐hydroxynaphthyl) benzothiazole complex [C] . Sattey Prakash, R. S. Anand, S. Sundar Manoharan International Conference on Light . 2011

机译：Exciplex形成对二聚体Zn（II）双-2-（2'-羟基苯基）苯并恶唑络合物和单体Zn（II）2-（1'-羟基萘基）苯并噻唑络合物的电致发光性能
5. Photophysical properties of ortho-metalated monomeric and dimeric complexes containing rhodium(III) and iridium(III) metal centers. [D] . Marshall, Jason Alexander. 2002

机译：含铑（III）和铱（III）金属中心的邻金属化单体和二聚配合物的光物理性质。
6. Optical DNA Biosensor Based on Square-Planar Ethyl Piperidine Substituted Nickel(II) Salphen Complex for Dengue Virus Detection [O] . Eda Yuhana Ariffin, Ling Ling Tan, Nurul Huda Abd. Karim, 2018

机译：基于方形平面乙基哌啶取代镍（II）赛尔芬配合物的光学DNA生物传感器用于登革热病毒检测
7. Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity by Square-Planar Nickel(II) Complexes [O] . -1

机译：通过平面平面镍（II）络合物稳定G-四反合DNA及其抑制来抑制端粒酶活性
8. The Preparation and Magnetic and Structural Examination of Monomeric, Dimeric,and Polymeric Adenine Complexes of Copper (II). [R] . brown,david b. hall,james w. 1977

机译：铜（II）单体，二聚体和聚合腺嘌呤配合物的制备，磁性和结构检测。

A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

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