Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

Xie Linlin; Zhi Xiaomin; Xiao Nao; Fang Chen-Jie; Yan Chun-Hua

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Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

机译：约束肽与Au nanorods的构象构建靶向，成像和光热能力的多功能治疗剂

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We demonstrated an easy-to-use strategy, instead of the tedious cyclization of the peptide backbone, to constrain the freedom of an RGD (arginine, glycine, aspartic acid) sequence with gold nanorods. We further constructed a multifunctional therapeutic agent which showed targeting, application in two-photon photoluminescence imaging, and near-infrared photothermal ability, suggesting the potential of this novel strategy in the development of RGD-containing drugs for biomedical applications.

机译：我们证明了一种易于使用的策略，而不是肽骨架的繁琐环化，以限制RGD（精氨酸，甘氨酸，天冬氨酸）序列与金纳米棒的自由度。我们进一步构建了一种多功能治疗剂，其显示靶向，在双光子光致发光成像和近红外光热的能力中，表明这种新颖的策略在含RGD药物中进行生物医学应用的潜力。

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《RSC Advances》 |2018年第47期|共6页
作者
Xie Linlin; Zhi Xiaomin; Xiao Nao; Fang Chen-Jie; Yan Chun-Hua;
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作者单位

Capital Med Univ Sch Pharmaceut Sci Beijing 100069 Peoples R China;

Capital Med Univ Sch Pharmaceut Sci Beijing 100069 Peoples R China;

Capital Med Univ Sch Pharmaceut Sci Beijing 100069 Peoples R China;

Capital Med Univ Sch Pharmaceut Sci Beijing 100069 Peoples R China;

Peking Univ Coll Chem &

Mol Engn Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem &

Applicat PKU Beijing 100871 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities [J] . Xie Linlin, Zhi Xiaomin, Xiao Nao, RSC Advances . 2018,第47期

机译：约束肽与Au nanorods的构象构建靶向，成像和光热能力的多功能治疗剂
2. Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities [J] . Linlin Xie, Xiaomin Zhi, Nao Xiao, RSC Advances . 2018,第47期

机译：用金纳米棒限制肽的构象，以构建具有靶向，成像和光热功能的多功能治疗剂
3. Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities [J] . Linlin Xie, Xiaomin Zhi, Nao Xiao, RSC Advances . 2018,第47期

机译：用金纳米棒限制肽的构象，以构建具有靶向，成像和光热功能的多功能治疗剂
4. Multifunctional PS@CS@Au-Fe3O4-FA Nanocomposites for CT,MR and Fluorescence Imaging Guided Targeted-Photothermal Therapy of Cancer Cells [C] . Yeying Wang, Xijian Liu, Guoying Deng, International Forum on Crystal Engineering and Smart Manufacturing;Tianjin University;Tianjin Science and Technology Association . -1

机译：用于CT，MR和荧光成像的多功能PS @ CS @ AU-FE3O4-FA纳米复合材料引导癌细胞的靶向光热疗法
5. Gold nanorods: Their properties and applications as biomarkers and photothermal therapeutic agents. [D] . Stone, John W. 2008

机译：金纳米棒：它们的性质和作为生物标志物和光热治疗剂的应用。
6. Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring β-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimers Disease [O] . Meng Li, Yijia Guan, Andong Zhao, 2017

机译：使用多功能肽共轭金纳米棒监测β-淀粉样蛋白聚集和化学光热治疗阿尔茨海默氏病
7. Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring β-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer's Disease [O] . Meng Li, Yijia Guan, Andong Zhao, 2017

机译：使用多官能肽缀合的Au纳米杆用于监测阿尔茨米默病的β-淀粉样蛋白聚集和化学光热处理

Constraining the conformation of peptides with Au nanorods to construct multifunctional therapeutic agents with targeting, imaging, and photothermal abilities

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