Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

Nian Yin; Lu Ni-Hong; Liu Xiao-Ling; Li Da-Shan; Zhou Lin; Qiu Ming-Hua

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Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

机译：来自Cimicifuga yunnanensis果实的抗腺苷酸酶三萜

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Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro [4.4] nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 mu M, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 mu M.

机译：含有基于环D和E的独特的Oxaspiro [4.4]壬烯部分部分的Cimyunnin e（1），与Cimicifine B（2）一起，具有吡啶环E的25,26,27-三体培养烯，是从Cimicifuga yunnanensis的果实纯化。它们的结构通过光谱方法和ECD（电子圆形二色性计算）阐明。化合物1和2显示出显着的乙酰胆碱酯酶（ACHE）抑制，IC 50值分别为1.58和3.87μm。此外，它们明显增强神经生长因子（NGF）介导的PC12细胞的神经沸石产量，以10μmm。

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来源
《RSC Advances》 |2018年第14期|共7页
作者
Nian Yin; Lu Ni-Hong; Liu Xiao-Ling; Li Da-Shan; Zhou Lin; Qiu Ming-Hua;
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作者单位

Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

Third Peoples Hosp Kunming Dept Resp Med Kunming 650041 Yunnan Peoples R China;

Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

Chinese Acad Sci Kunming Inst Bot State Key Lab Phytochem &

Plant Resources West Ch Kunming 650201 Yunnan Peoples R China;

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正文语种 eng
中图分类化学;
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Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

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