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Fabrication of a microfluidic chip based on the pure polypropylene material

机译:基于纯聚丙烯材料的微流体芯片制备

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摘要

Polypropylene (PP) material has been widely used in the biomedical field for decades due to its high reliability in biochemical reactions. However, a pure PP material microfluidic chip has rarely been reported. Herein, a simple and rapid method has been developed to fabricate a pure PP microfluidic chip by a thermal bonding process using a PP film and PP substrate. An experiment for two-temperature PCR in the pure PP microfluidic system without a pre-treatment process has been successfully carried out. It is shown that the PP microfluidic chip has a high structural strength, tightness for water sealing, and low nonspecific adsorption, which promotes the practical application of microfluidics in the biomedical field. Compared to other existing microfluidic chip technologies, our pure PP material microfluidic chip and its fabrication method have many advantages such as high-speed production rate and extremely low cost. It can be achieved in industrial assembly lines for standardized manufacturing.
机译:由于其在生化反应的高可靠性,聚丙烯(PP)材料已广泛用于生物医学领域。然而,很少报道纯PP材料微流体芯片。这里,已经开发了一种简单且快速的方法,通过使用PP膜和PP衬底通过热粘合工艺制造纯PP微流体芯片。已经成功地成功地进行了在没有预处理过程的纯PP微流体系统中的两个温度PCR的实验。结果表明,PP微流体芯片具有高结构强度,水密封的紧密性,促进了微流体在生物医学领域的实际应用。与其他现有的微流体芯片技术相比,我们的纯PP材料微流体芯片及其制造方法具有许多优点,如高速生产率和极低成本。它可以在工业装配线中实现标准化制造。

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  • 来源
    《RSC Advances》 |2018年第16期|共7页
  • 作者单位

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

    Stanford Univ Dept Bioengn 443 Via Ortega Stanford CA 94305 USA;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

    Southeast Univ Sch Biol Sci &

    Med Engn State Key Lab Bioelect 2 Si Pai Lou Nanjing 210096 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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