• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Toxic effects of zinc oxide nanoparticles combined with vitamin C and casein phosphopeptides on gastric epithelium cells and the intestinal absorption of mice
【24h】

Toxic effects of zinc oxide nanoparticles combined with vitamin C and casein phosphopeptides on gastric epithelium cells and the intestinal absorption of mice

机译：氧化锌纳米颗粒与维生素C和酪蛋白磷矿肽对胃膜细胞的毒性作用及小鼠的肠道吸收

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Zinc oxide nanomaterials have become common food additives in recent years. Casein phosphopeptides (CPP) and vitamin C (VC) are used as functional food additives together with ZnO nanoparticles (ZnO NPs) in many commercial foods. Our previous studies showed that VC can increase the cytotoxicity induced by ZnO NPs both in vitro and in vivo, while CPP can have a cytoprotective effect against oxidative stress induced by ZnO NPs. However, the combined toxic effect of the three additives together in food is unknown. Herein, we have investigated the combined toxicity of ZnO NPs, CPP and VC by altering the sequence of their addition to clarify their toxic mechanisms in the composite systems. When the order of addition of the three materials changes, the cytotoxicity induced by the ZnO NPs changes due to the different concentrations of dissolved Zn ions in the different groups. We have also probed the intestinal absorption of Zn ions with an everted gut sac model. The amount of Zn2+ absorbed in the intestine in different composite systems also responds differently to the sequence of addition of the additives. VC is more powerful at controlling the synergistic toxic effect induced by ZnO NPs compared to the protective role of CPP in the combined systems.
机译：氧化锌纳米材料近年来已成为常见的食品添加剂。酪蛋白磷酸肽（CPP）和维生素C（VC）用作许多商业食品中与ZnO纳米颗粒（ZnO NPS）一起用作官能食品添加剂。我们以前的研究表明，VC可以在体外和体内增加ZnO NPS诱导的细胞毒性，而CPP可以对ZnO NPS引起的氧化应激具有细胞保护作用。然而，三种添加剂在食物中的组合毒性作用是未知的。在此，我们通过改变其补充序列来研究ZnO NPS，CPP和Vc的组合毒性，以澄清它们在复合系统中的毒性机制。当增加三种材料的顺序发生变化时，ZnO NPS诱导的细胞毒性由于不同基团中的不同浓度的溶解Zn离子而变化。我们还探讨了Zn离子的肠道吸收与永恒的肠道模型。在不同复合体系中的肠道中吸收的Zn2 +的量也与添加剂的添加序列不同。与CPP在组合系统中的保护作用相比，VC更强大地控制ZnO NPS诱导的协同毒性效果。

著录项

  • 来源
    《RSC Advances》 |2018年第46期|共11页
  • 作者

    Gu Tianjiao; Yao Chenjie; Zhang Kangkang; Li Chenchen; Ding Lin; Huang Yanan; Wu Minghong; Wang Yanli;

  • 作者单位

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

    Shanghai Univ Sch Environm &

    Chem Engn Shanghai Peoples R China;

    Shanghai Univ Inst Nanochem &

    Nanobiol Shanghai Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号