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首页> 外文期刊>RSC Advances >MiR-320d suppresses the progression of breast cancer via lncRNA HNF1A-AS1 regulation and SOX4 inhibition
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MiR-320d suppresses the progression of breast cancer via lncRNA HNF1A-AS1 regulation and SOX4 inhibition

机译：MiR-320D通过LNCRNA HNF1A-AS1调节抑制乳腺癌的进展和SOX4抑制

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摘要

MicroRNA-320d (miR-320d) is a novel cancer-related miRNA and functions as a tumor suppressor in human cancers. However, the expression pattern and function of miR-320d in breast cancer remain largely unknown. In the present study, we found that the expression level of miR-320d in breast cancer tissues and cells was significantly lower than in non-tumor tissues and MCF-10A cells. Decreased miR-320d was associated with poor overall survival in patients with breast cancer. Overexpression of miR-320d inhibited proliferation, migration, and invasion and promoted apoptosis of breast cancer cells. In addition, the long non-coding RNA, HNF1A antisense RNA 1 (HNF1A-AS1) was up-regulated in both breast cancer tissues and cell lines. HNF1A-AS1 suppressed the expression and function of miR-320d. Moreover, SRY-related HMG-box 4 (SOX4) was speculated and confirmed as a target of miR-320d. We also demonstrated that HNF1A-AS1 may function as a sponge competitive endogenous RNA for miR-320d, and thus regulate the expression of SOX4. Taken together, our study has identified a novel signaling pathway through which miR-320d exerts its anti-carcinogenic roles and suggested that the HNF1A-AS1/miR-320d/SOX4 may be a potential target for the therapy of breast cancer.
机译：MicroRNA-320D（miR-320d）是一种新型癌症相关的miRNA，并用作人类癌症中的肿瘤抑制剂。然而，乳腺癌中miR-320d的表达模式和功能仍然很大程度上是未知的。在本研究中，我们发现乳腺癌组织和细胞中miR-320d的表达水平显着低于非肿瘤组织和MCF-10a细胞。 MiR-320D减少与乳腺癌患者的整体存活差有关。 MiR-320D的过度表达抑制增殖，迁移和侵袭，促进乳腺癌细胞的凋亡。另外，在乳腺癌组织和细胞系中，长期非编码RNA，HNF1a反义RNA 1（HNF1A-AS1）上调。 HNF1A-AS1抑制了MIR-320D的表达和功能。此外，推测Sry相关的HMG盒4（SOX4）并证实miR-320D的靶标。我们还证明了HNF1A-AS1可以用作MIR-320D的海绵竞争内源性RNA，从而调节SOX4的表达。我们的研究鉴定了一种新的信号传导途径，MiR-320D发挥其抗癌作用，并表明HNF1A-AS1 / miR-320D / SOX4可以是乳腺癌治疗的潜在目标。

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  • 来源
    《RSC Advances》 |2018年第34期|共12页
  • 作者

    Shi Shuai; Hu Xiaoling; Xu Jianpo; Liu Hong; Zou Libo;

  • 作者单位

    Zhejiang Normal Univ Jinhua Peoples Hosp Reprod Med Ctr Biomed Res Ctr Jinhua 321000 Peoples R China;

    Zhejiang Univ Dept Reprod Endocrinol Sch Med Affiliated Obstet &

    Gynecol Hosp Hangzhou 310006 Zhejiang Peoples R China;

    Zhejiang Univ Life Sci Inst Hangzhou 310058 Zhejiang Peoples R China;

    Zhejiang Normal Univ Jinhua Peoples Hosp Reprod Med Ctr Biomed Res Ctr Jinhua 321000 Peoples R China;

    Zhejiang Normal Univ Jinhua Peoples Hosp Reprod Med Ctr Biomed Res Ctr Jinhua 321000 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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