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首页> 外文期刊>RSC Advances >Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation
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Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation

机译：从Pogostemon Cablin的叶子中分离的广藿香油可以通过抑制氧化应激和脂质积累来改善大鼠乙醇诱导的急性肝损伤

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摘要

Excessive alcohol consumption can cause serious hepatic injury which is associated with oxidative stress and fatty metabolic disturbance. Patchouli oil (PO) is a sort of food supplement with high medicinal value in hepatoprotection, but its ability against ethanol-induced liver failure has not been demonstrated. Thus, this study aimed to investigate the potential hepatoprotection of PO through an ethanol-induced hepatotoxicity rat model. Our results showed that PO pretreatment could dramatically decrease the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in serum, paralleled by an improvement of histopathology alterations. Additionally, PO could markedly suppress the content of reactive oxygen species (ROS), tumor necrosis factor alpha (TNF-alpha), free fatty acid (FFA), and triglyceride (TG), while enhancing the activities of glutathione (GSH), glutathione reductase (GR), and superoxide dismutase (SOD) as well as the ratio of glutathione to oxidized glutathione (GSH/GSSG) in liver. The protective effect of PO against oxidative stress was interrelated with restraining the mRNA and protein expression of hepatic microsomal enzyme cytochrome P450 2E1 (CYP2E1). What's more, PO pretreatment could also accelerate lipometabolism via up-regulating expressions of adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPAR-alpha), and carnitine palmitoyltransferase 1 (CPT-1) and down-regulating expressions of nuclear factor-kappaB (NF-kappa B) p65, sterol regulatory element-binding protein 1 (SREBP-1c), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD-1). To conclude, PO showed potent effect against ethanol-induced hepatotoxicity by relieving oxidative stress and preventing lipid accumulation.
机译：过量的醇消耗会导致严重的肝损伤，这与氧化应激和脂肪代谢干扰有关。 Paprouli Oil（Po）是一种具有高药物价值的食物补充，但其抗乙醇诱导的肝功能衰竭能力尚未证明。因此，本研究旨在通过乙醇诱导的肝毒性大鼠模型来研究PO的潜在肝脏应激。我们的研究结果表明，血清中丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）的水平显着降低，并通过改善组织病理学改变而平行。另外，PO可以显着抑制反应性氧物质（ROS），肿瘤坏死因子α（TNF-α），游离脂肪酸（FFA）和甘油三酯（TG）的含量，同时增强谷胱甘肽（GSH），谷胱甘肽的活性还原酶（GR）和超氧化物歧化酶（SOD）以及谷胱甘肽与肝脏氧化谷胱甘肽（GSH / GSSG）的比例。 Po抗氧化应激的保护作用与抑制肝微粒体酶细胞色素p4502e1（CYP2E1）的mRNA和蛋白表达相互关联。更重要的是，PO预处理也可以通过腺苷一磷酸胺激活蛋白激酶（AMPK），过氧化物酶增殖物激活的受体α（PPAR-1）和肉氨基棕榈酰基转移酶1（CPT-1）和下调核因子-κB（NF-KAPPA B）P65，甾醇调节元素结合蛋白1（SrebP-1C），脂肪酸合酶（Fas）和硬脂酰-CoA去饱和酶1（SCD-1）的表达。结论，PO通过缓解氧化应激和预防脂质积累来表现出对乙醇诱导的肝毒性的有效效果。

著录项

  • 来源
    《RSC Advances》 |2018年第43期|共12页
  • 作者

    Huang Qiong-Hui; Wu Xue; Chen Xiao-Hong; Wu Jia-Zhen; Su Zi-Ren; Liang Jia-Li; Li Yu-Cui; Lai Xiao-Ping; Chen Jian-Nan; Liu Yu-Hong;

  • 作者单位

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Affiliated Hosp Chinese Med 1 12 Airport Rd Guangzhou 510405 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Guangdong Prov Key Lab New Drug Dev &

    Res Chinese Math Engn Acad Chinese Med Guangzhou Higher Educ Mega Ctr 232 Wai Huan East Rd Guangzhou 510006 Guangdong Peoples R China;

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