Nanodiamond-based layer-by-layer nanohybrids mediate targeted delivery of miR-34a for triple negative breast cancer therapy

Xia Yang; Deng Xiongwei; Cao Minjun; Liu Sha; Zhang Xiaofei; Xiao Xiangqian; Shen Sisi; Hu Qin; Sheng Wang

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Nanodiamond-based layer-by-layer nanohybrids mediate targeted delivery of miR-34a for triple negative breast cancer therapy

机译：基于纳米金刚胺的逐层纳米嗜型介导针对三重阴性乳腺癌治疗的MiR-34a的靶向递送

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Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer and significantly associated with poor prognosis and high risk of recurrence. miR-34a has been identified as a potent tumor suppressor whose expression is dramatically downregulated in TNBC. Currently, rectification of miRNA abnormality serves as a novel tumor therapeutic strategy. miR-34a is thus used as powerful antitumor agent for miRNA-based therapy against TNBC. However, miRNA-based antitumor therapy is challenged by effective targeted delivery of miRNA. In the present study, nanodiamond (ND), protamine (PS) and folic acid (FA) were used to construct ND-based layer-by-layer nanohybrids through a self-assembly approach for targeted miR-34a delivery in TNBC cells and xenograft TNBC tumors. We found that the targeted delivery of miR-34a remarkably suppressed cell proliferation, migration and induced the apoptosis of TNBC cells in vitro and inhibited tumor growth in vivo via down-regulating Fra-1 expression. The data suggest a great potential of ND-based nanohybrids for targeted intratumoral delivery of miR-34a for TNBC therapy.

机译：三阴性乳腺癌（TNBC）是乳腺癌的最致命的亚型预后差，复发的高风险显著相关。的miR-34a的已被鉴定为一种有效的肿瘤抑制剂，其表达在TNBC急剧下调。目前，miRNA的异常整流用作一种新的肿瘤的治疗策略。由此的miR-34a的被用作强大的抗肿瘤剂针对TNBC基于miRNA的疗法。然而，基于miRNA的抗肿瘤治疗是通过miRNA的有效靶向递送的挑战。在本研究中，纳米金刚石（ND），鱼精蛋白（PS）和叶酸（FA）中使用通过在TNBC细胞和异种移植靶向的miR-34a的递送的自组装方法来构造基于ND-层 - 层纳米复合物TNBC肿瘤。我们发现了miR-34a的靶向递送显着地抑制细胞增殖，迁移并诱导TNBC细胞在体外和体内通过下调FRA-1的表达抑制肿瘤生长的细胞凋亡。这些数据表明基于ND-纳米复合物，用于治疗三阴性乳腺癌靶向肿瘤内交付的miR-34a的一个极具潜力。

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《RSC Advances》 |2018年第25期|共9页
作者
Xia Yang; Deng Xiongwei; Cao Minjun; Liu Sha; Zhang Xiaofei; Xiao Xiangqian; Shen Sisi; Hu Qin; Sheng Wang;
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Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

Beijing Univ Technol Coll Life Sci &

Bioengn 100 Pingleyuan Beijing Peoples R China;

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中图分类化学;
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1. Nanodiamond-based layer-by-layer nanohybrids mediate targeted delivery of miR-34a for triple negative breast cancer therapy [J] . Xia Yang, Deng Xiongwei, Cao Minjun, RSC Advances . 2018,第25期

机译：基于纳米金刚胺的逐层纳米嗜型介导针对三重阴性乳腺癌治疗的MiR-34a的靶向递送
2. Tumor-Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel-Enhanced Immunotherapy with Polarization toward Ml-Type Macrophages on Triple Negative Breast Cancers [J] . Chen Lv, Zhou Lulu, Wang Chunhui, Advanced Materials . 2019,第52期

机译：肿瘤靶向药物和CpG传递系统用于三联阴性乳腺癌的光疗和多西他赛增强免疫治疗，对Ml型巨噬细胞具有极化作用。
3. AN INTEGRATED APPROACH OF BIOINFORMATIC PREDICTION AND IN VITRO ANALYSIS IDENTIFIED THAT MIR-34A TARGETS iMET/i AND iAXL/i IN TRIPLE-NEGATIVE BREAST CANCER [J] . Shadan Hajalirezay Yazdi, Mahdi Paryan, Samira Mohammadi-Yeganeh Cellular & molecular biology letters. . 2018,第3期

机译：生物信息化预测和体外分析的综合方法鉴定了miR-34a靶靶在三阴性乳腺癌中达到了和 AXL
4. Co-delivery of chemo drug and siRNA using layer-by-layer nanoparticles for triple negative breast cancer treatment [C] . Jason Z. Deng, Stephen Morton, Paula Hammond Society for biomaterials annual meeting and exposition . 2013

机译：使用层状纳米颗粒共同递送化学药物和siRNA用于三阴性乳腺癌的治疗
5. Extracellular Vesicles: Isolation with Multivalent Aptamers and Conferring Receptors to Triple-Negative Breast Cancer Cells for Targeted Drug Delivery [D] . Xue, Fei. 2022

机译：细胞外囊泡：用多价适体分离，并赋予三阴性乳腺癌细胞的受体进行靶向药物递送
6. An integrated approach of bioinformatic prediction and in vitro analysis identified that miR-34a targets MET and AXL in triple-negative breast cancer [O] . Shadan Hajalirezay Yazdi, Mahdi Paryan, Samira Mohammadi-Yeganeh 2018

机译：生物信息学预测和体外分析的综合方法确定了miR-34a靶向三阴性乳腺癌中的MET和AXL
7. Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy [O] . Amita M Vaidya, Zhanhu Sun, Nadia Ayat, 2019

机译：针对致癌的LNCRNA的肿瘤靶向siRNA纳米颗粒的全身递送促进了有效的三阴性乳腺癌治疗
8. Targeting MUC1-Mediated Tumor-Stromal Metabolic Interaction in Triple-Negative Breast Cancer. [R] . Singh, P. 2016

机译：针对三阴性乳腺癌中mUC1介导的肿瘤 - 基质代谢相互作用。

Nanodiamond-based layer-by-layer nanohybrids mediate targeted delivery of miR-34a for triple negative breast cancer therapy

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