A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

Yepremyan Akop; Mehmood Arshad; Brewer Samantha M.; Barnett Madalyn M.; Janesko Benjamin G.; Akkaraju Giridhar; Simanek Eric E.; Green Kayla N.

首页> 外文期刊>RSC Advances >A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

【24h】

A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

机译：一种轴承铜，镍和锌螯合剂的新三嗪

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Interest in inorganic applications of triazines is growing. In this report, metal complexes of copper(II), nickel(II), and zinc(II) and a novel class of chelates composed of a triazine ring substituted with a hydrazine group and pyrazolone are evaluated using spectrophotometric methods, single crystal X-ray diffractometry, and electrochemistry. Complexes with copper(II) include a single chelate and chloride ion(s)/water to satisfy a trigonal bipyramidal coordination sphere. The nickel(II) and zinc(II) complexes are composed of two chelating groups that adopt an octahedral geometry around the metal ion. Irreversible redox activity was observed with the copper(II) complex but no redox activity was observed with the ligand alone or zinc(II) and nickel(II) complexes. Use of the coumarin carboxylic acid assay shows that the ligand motif is capable of preventing redox cycling of copper in biological conditions and could thus serve as an antioxidant preventative agent. Cellular toxicity studies show that the new triazine molecule could have therapeutic applications in the mM concentration range based on the measured EC50 = 1.183 +/- 0.002 mM. Altogether this work shows that by merging triazine chemistry into inorganic compounds, there is potential to explore a range applications thanks to the new architecture.

机译：三嗪无机应用的兴趣正在增长。在本报告中，使用分光光度法评估用分光光度法，单晶X-取代的三嗪环组成的铜（II），镍（II），镍（II）和锌（II）和锌（II）和锌（II）的新型螯合物组成。射线衍射测定和电化学。铜（II）的配合物包括单个螯合和氯离子/水，以满足Trigonal双滤网配位球体。镍（II）和锌（II）配合物由两种螯合基团组成，其在金属离子周围采用八面体几何形状。用铜（II）复合物观察到不可逆的氧化还原活性，但没有用单独的配体或锌（II）和镍（II）配合物观察氧化还原活性。使用香豆素羧酸测定结果表明，配体基质能够防止生物条件中铜的氧化还原循环，因此可以用作抗氧化剂预防剂。细胞毒性研究表明，新的三嗪分子可以基于测量的EC50 = 1.183 +/- 0.002mm具有MM浓度范围内的治疗应用。完全是这项工作表明，通过将三嗪化学合并到无机化合物中，借助新的架构探讨了范围应用。

著录项

来源
《RSC Advances》 |2018年第6期|共12页
作者
Yepremyan Akop; Mehmood Arshad; Brewer Samantha M.; Barnett Madalyn M.; Janesko Benjamin G.; Akkaraju Giridhar; Simanek Eric E.; Green Kayla N.;
展开▼
作者单位

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

Texas Christian Univ Dept Biol Ft Worth TX 76129 USA;

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

Texas Christian Univ Dept Chem &

Biochem Ft Worth TX 76129 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation [J] . Yepremyan Akop, Mehmood Arshad, Brewer Samantha M., RSC Advances . 2018,第6期

机译：一种轴承铜，镍和锌螯合剂的新三嗪
2. Synthesis and structural characterization of three hydrogen-bonding connected supramolecular complexes of nickel, zinc and copper with 1,3-diphenyl-4-(salicylidene hydrazide)acetyl-pyrazolone-5 and 2,2 '-bipyridine [J] . Hu X, Zhang L, Liu L, Inorganica Chimica Acta . 2006,第2期

机译：镍，锌和铜的三种氢键连接的超分子配合物与1,3-二苯基-4-（水杨酰肼）乙酰基-吡唑酮-5和2,2'-联吡啶的合成及结构表征
3. Potentiometric Studies on the Chelation of Pyrazole-3, 5-Dicarboxylic acid with Cobalt(II), Nickel(II), Copper(II), Zinc(II), Cadmium(II) and Lead(II) in Dioxan Medium [J] . R.K. Mahajan, Manoj Kumar, Vandana Sharma Journal of the Electrochemical Society of India . 2001,第2期

机译：二恶烷介质中吡唑-3、5-二羧酸与钴（II），镍（II），铜（II），锌（II），镉（II）和铅（II）螯合的电位研究
4. RECOVERY OF ZINC FROM ZINC WASTE GALVANIC SLUDGES WITH INCREASED COPPER AND NICKEL CONTENT [C] . Jitka Jandova, Petr Dvorak, VladimirJiricny Global Symposium on Recycling, Waste Treatment and Clean Technology; 20040926-29; Madrid(ES) . 2004

机译：从含铜和镍含量增加的废锌电镀废料中回收锌
5. THE STUDY OF REACTIONS IN AQUEOUS-NONAQUEOUS SYSTEMS BY DIFFERENTIAL THERMOMETRIC TITRIMETRY. THE PRECIPITATION OF SILVER HALIDES AND SOME CHELATION REACTIONS OF DIVALENT COBALT, NICKEL, COPPER, AND ZINC. [D] . JEZOREK, JOHN ROBERT. 1969

机译：差示热计量滴定法研究水-非水体系中的反应卤化银的沉淀以及不同钴，镍，铜和锌的某些HEL变反应。
6. A new triazine bearing a pyrazolone group capable of copper nickel and zinc chelation [O] . Akop Yepremyan, Arshad Mehmood, Samantha Brewer, -1

机译：带有吡唑啉酮基团的新型三嗪能够与铜镍和锌螯合
7. A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation [O] . Akop Yepremyan, Arshad Mehmood, Samantha M. Brewer, 2018

机译：一种轴承铜，镍和锌螯合剂的新三嗪
8. Corrosion of Copper--Zinc and Copper--Nickel Alloys in a Geothermal Brine [R] . Miller, R. L. 1978

机译：铜锌和铜镍合金在地热盐水中的腐蚀

A new triazine bearing a pyrazolone group capable of copper, nickel, and zinc chelation

摘要

著录项

相似文献

相关主题

期刊订阅