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首页> 外文期刊>RSC Advances >Biocompatible tumor-targeting nanocomposites based on CuS for tumor imaging and photothermal therapy
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Biocompatible tumor-targeting nanocomposites based on CuS for tumor imaging and photothermal therapy

机译：基于CU的生物相容性肿瘤靶向纳米复合材料，用于肿瘤成像和光热疗法

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摘要

Active targeting of tumor receptors is a significant approach for cancer diagnosis. Additionally, development of photothermal agents for photothermal therapy (PTT) has attracted great interest in the field of nanomedicine. In the present study, copper sulfide (CuS) nanoparticles capped with bovine serum albumin (BSA), named CuS@BSA, was synthesized by a convenient method. Then, the near-infrared (NIR) fluorescence probe MBA and the tumor-targeting ligand cyclic RGD were further conjugated on the surface of CuS@BSA, and the obtained nanocomposite was named CuS@BSA-MBA-cRGD. The morphology, optical properties, biotoxicity, tumor-targeting capability and in vitro and in vivo tumor inhibition effect were all characterized comprehensively. This nanocomplex demonstrated enhanced photothermal effects and positive tumor targeting. Thus, the nanocomposite CuS@BSA-MBA-cRGD can used as a promising tumor-targeting PTT agent for simultaneous cancer imaging and photothermal treatment.
机译：肿瘤受体的活性靶向是癌症诊断的重要方法。 另外，用于光热疗法的光热试剂（PTT）的发育引起了对纳米卫生素领域的兴趣。 在本研究中，通过方便的方法合成了用牛血清白蛋白（BSA）的硫化铜（CUS）纳米颗粒用牛血清白蛋白（BSA）。 然后，近红外（NIR）荧光探针MBA和肿瘤靶向配体环状RGD在CUS @ BSA的表面上进一步缀合，并将所得纳米复合物命名为CUS @ BSA-MBA-CRGD。 全部表征了形态，光学性质，生物毒性，肿瘤靶向能力和体外和体内肿瘤抑制作用。 该纳米键合术语显示出增强的光热效应和阳性肿瘤靶向。 因此，纳米复合材料CUS @ BSA-MBA-CRGD可用作具有同时癌症成像和光热处理的有前途的肿瘤靶向PTT剂。

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  • 来源
    《RSC Advances》 |2018年第11期|共14页
  • 作者

    Liang Li; Peng Shuwen; Yuan Zhenwei; Wei Chen; He Yuanyuan; Zheng Jinrong; Gu Yueqing; Chen Haiyan;

  • 作者单位

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

    China Pharmaceut Univ Sch Engn Dept Biomed Engn 24 Tongjia Lane Nanjing 210009 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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