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首页> 外文期刊>RSC Advances >Terminal aspartic acids promote the self-assembly of collagen mimic peptides into nanospheres
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Terminal aspartic acids promote the self-assembly of collagen mimic peptides into nanospheres

机译：末端天冬氨酸促进胶原蛋白模拟肽的自组装成纳米球

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摘要

The development of novel strategies to construct collagen mimetic peptides capable of self-assembling into higher-order structures plays a critical role in the discovery of functional biomaterials. We herein report the construction of a novel type of amphiphile-like peptide conjugating the repetitive triple helical (GPO)(m) sequences characteristic of collagen with terminal hydrophilic aspartic acids. The amphiphile-like collagen mimic peptides containing a variable length of (Gly-Pro-Hyp)(m) sequences consistently generate well-ordered nanospherical supramolecular structures. The C-terminal aspartic acids have been revealed to play a determinant role in the appropriate self-assembly of amphiphile-like collagen mimic peptides. Their presence is a prerequisite for self-assembly, and their lengths could modulate the morphology of final assemblies. We have demonstrated for the first time that amphiphile-like collagen mimic peptides with terminal aspartic acids may provide a general and convenient strategy to create well-defined nanostructures in addition to amphiphile-like peptides utilizing beta-sheet or alpha-helical coiled-coil motifs. The newly developed assembly strategy together with the ubiquitous natural function of collagen may lead to the generation of novel improved biomaterials.
机译：构建能够自组装成高阶结构的胶原蛋白模拟肽的新策略的发展在发现功能生物材料中起着关键作用。我们在此报告了缀合物与末端亲水性天冬氨酸缀合的重复三重螺旋（GPO）（M）序列的重复三重螺旋（GPO）（M）序列序列的新型两亲性肽的构建。含有可变长度（GLY-PRO-HYP）（M）序列的两亲的胶原蛋白肽始终产生良好有序的纳米球体超分子结构。已揭示C末端天冬氨酸在适当的两亲胶原模拟肽的适当自组装中起决定性作用。他们的存在是自组装的先决条件，它们的长度可以调节最终组件的形态。我们首次证明了具有末端天冬氨酸的两亲物质的胶原蛋白肽可以提供一种常规和方便的策略，以产生利用β-片或α-螺旋卷绕式线圈基序的两亲型肽制造明确的纳米结构。新开发的装配策略与胶原蛋白的无处不存在的自然功能一起可能导致新型改善生物材料的产生。

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  • 来源
    《RSC Advances》 |2018年第5期|共6页
  • 作者

    Yao Linyan; He Manman; Li Dongfang; Tian Jing; Liu Huanxiang; Xiao Jianxi;

  • 作者单位

    Lanzhou Univ Coll Chem &

    Chem Engn State Key Lab Appl Organ Chem Key Lab Nonferrous Meta Chem &

    Resources Utilizat Lanzhou 730000 Gansu Peoples R China;

    Lanzhou Univ Coll Chem &

    Chem Engn State Key Lab Appl Organ Chem Key Lab Nonferrous Meta Chem &

    Resources Utilizat Lanzhou 730000 Gansu Peoples R China;

    Lanzhou Univ Coll Chem &

    Chem Engn State Key Lab Appl Organ Chem Key Lab Nonferrous Meta Chem &

    Resources Utilizat Lanzhou 730000 Gansu Peoples R China;

    Lanzhou Univ Coll Chem &

    Chem Engn State Key Lab Appl Organ Chem Key Lab Nonferrous Meta Chem &

    Resources Utilizat Lanzhou 730000 Gansu Peoples R China;

    Lanzhou Univ Sch Pharm Lanzhou 730000 Gansu Peoples R China;

    Lanzhou Univ Coll Chem &

    Chem Engn State Key Lab Appl Organ Chem Key Lab Nonferrous Meta Chem &

    Resources Utilizat Lanzhou 730000 Gansu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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