A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

Fu Yingjie; Feng Qishuai; Shen Yajing; Chen Mengwei; Xu Chang; Cheng Yu; Zhou Xiang

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A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

机译：通过DITHIOL-PEG进行金纳米粒子自组装的可行策略，用于癌症光热疗法

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摘要

We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.

机译：我们通过引入二硫醇改性的聚乙二醇（PEG）来设计和探索自组装的金纳米颗粒（SAGNP），用于间晶体交联。 SAGNP可以增强吸收癌细胞并通过谷胱甘肽（GSH）解体以实现肿瘤微环境活化的生物降解。与单金纳米球相比，这种组装结构改善了光热效应。

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《RSC Advances》 |2018年第11期|共5页
作者
Fu Yingjie; Feng Qishuai; Shen Yajing; Chen Mengwei; Xu Chang; Cheng Yu; Zhou Xiang;
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作者单位

Wuhan Univ Inst Adv Studies Wuhan 430072 Hubei Peoples R China;

Tongji Univ Shanghai East Hosp Inst Biomed Engn &

Nano Sci Sch Med Shanghai 200029 Peoples R China;

Tongji Univ Shanghai East Hosp Inst Biomed Engn &

Nano Sci Sch Med Shanghai 200029 Peoples R China;

Tongji Univ Shanghai East Hosp Inst Biomed Engn &

Nano Sci Sch Med Shanghai 200029 Peoples R China;

Tongji Univ Shanghai East Hosp Inst Biomed Engn &

Nano Sci Sch Med Shanghai 200029 Peoples R China;

Tongji Univ Shanghai East Hosp Inst Biomed Engn &

Nano Sci Sch Med Shanghai 200029 Peoples R China;

Wuhan Univ Inst Adv Studies Wuhan 430072 Hubei Peoples R China;

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正文语种 eng
中图分类化学;
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1. A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers [J] . Fu Yingjie, Feng Qishuai, Shen Yajing, RSC Advances . 2018,第11期

机译：通过DITHIOL-PEG进行金纳米粒子自组装的可行策略，用于癌症光热疗法
2. mRNA Guided Intracellular Self-Assembly of DNA-Gold Nanoparticle Conjugates as a Precise Trigger to Up-Regulate Cell Apoptosis and Activate Photothermal Therapy [J] . Ye Wanying, Li Huan, Li Xu, Bioconjugate Chemistry . 2019,第6期

机译：mRNA引导DNA-金纳米粒子缀合物的细胞内自组装作为精确的触发到上调细胞凋亡并激活光热疗法
3. Self-Assembly of Semiconducting-Plasmonic Gold Nanoparticles with Enhanced Optical Property for Photoacoustic Imaging and Photothermal Therapy [J] . Zhen Yang, Jibin Song, Yunlu Dai, Theranostics . 2017,第8期

机译：具有增强的光学性质的半导体-等离子体金纳米粒子的自组装，用于光声成像和光热疗法
4. Bifunctional Gold Nanoparticle for Tracking Cancer and Treatment by Photothermal Therapy [C] . Kabir S. Dhada, Laura J. Suggs Society for Biomaterials annual meeting and exposition . 2017

机译：双功能金纳米颗粒用于追踪癌症和光热疗法的治疗
5. Molecularly-Targeted Gold-Based Nanoparticles for Cancer Imaging and Near-Infrared Photothermal Therapy [D] . Day, Emily Shannon 2011

机译：分子靶向金基纳米颗粒用于癌症成像和近红外光热疗法
6. Self-Assembly of Semiconducting-Plasmonic Gold Nanoparticles with Enhanced Optical Property for Photoacoustic Imaging and Photothermal Therapy [O] . Zhen Yang, Jibin Song, Yunlu Dai, 2017

机译：具有增强的光学性能的半导体-等离子体金纳米颗粒的自组装用于光声成像和光热疗法
7. Self-assembly of gold supraparticles with crystallographically aligned and strongly coupled nanoparticle building blocks for SERS and photothermal therapy [O] . Paterson, S., Thompson, S. A., Gracie, J., 2016

机译：具有晶体学排列和强耦合的纳米粒子结构单元的金超粒子的自组装，用于SERS和光热疗法

A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

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