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Osteogenic capacity of mixed-acid and heat-treated titanium mesh prepared by a selective laser melting technique

机译：通过选择性激光熔化技术制备的混合酸和热处理钛网的成骨容量

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摘要

The practical use of additive manufacturing to create artificial bone as a material for repairing complex bone defects is currently attracting attention. In this study, we compared the osteogenic capacity of materials composited by the method developed by Kokubo et al. of treating 3D-printed titanium (Ti) mesh with a mixture of H2SO4 and HCl and heating (mixed-acid and heat treatment) with that of materials subjected to conventional chemical treatment. Ti plates treated with this method have been found to promote highly active bone formation on their surface when inserted into rabbit tibial bone defects. No previous study has compared this method with other surface treatment methods. In this study, we used histological and other observations to compare the bone formation process in bone defects when Ti meshes prepared by the selective laser melting technique (SLM) and treated either with mixed acids and heat or with conventional chemical Ti surface treatments were implanted in a rat calvarial bone defect model. We found that both micro-computed tomography and observations of undecalcified ground sections showed that the best bone formation was observed in rats implanted with mesh treated with mixed acids and heat. Our results suggest that mixed-acid and heat-treated Timesh prepared by SLM may have a high osteogenic capacity in bone defects.
机译：添加剂制造的实际用途以制造人造骨作为修复复杂骨缺损的材料目前正在引起关注。在这项研究中，我们将通过Kokubo等人开发的方法进行了比较了材料的骨质原性能力。用H 2 SO 4和HCl的混合物处理3D印刷钛（Ti）网，并具有经受常规化学处理的材料的加热（混合酸和热处理）。已经发现用该方法治疗的Ti平板在插入兔胫骨骨缺损时促进其表面上的高活性骨形成。以前没有研究这种方法与其他表面处理方法进行了比较。在本研究中，当通过选择性激光熔化技术（SLM）制备并用混合酸和热量或常规化学Ti表面处理来进行组织学和其他观察，将骨缺损中的骨形成过程比较骨缺陷中的骨形成过程大鼠颅骨骨缺陷模型。我们发现，两种微型计算断层扫描和未检测到的地面部分的观察结果表明，在用混合酸和热处理的网格中植入网格中观察到最佳骨形成。我们的研究结果表明，通过SLM制备的混合酸和热处理的时间可以具有高骨缺损的高骨质骨质能力。

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  • 来源
    《RSC Advances》 |2018年第46期|共9页
  • 作者

    Yamamoto Kayoko; Yamaguchi Seiji; Matsushita Tomiharu; Mori Shigeo; Hirata Azumi; Kato-Kogoe Nahoko; Nakano Hiroyuki; Nakajima Yoichiro; Nishitani Yoshihiro; Nagatsuka Hitoshi; Ueno Takaaki;

  • 作者单位

    Osaka Med Coll Div Med Funct &

    Morphol Sensor Organ Dent &

    Oral 2-7 Daigaku Machi Takatsuki Osaka 5698686 Japan;

    Chubu Univ Coll Life &

    Hlth Sci Dept Biomed Sci Kasugai Aichi Japan;

    Chubu Univ Coll Life &

    Hlth Sci Dept Biomed Sci Kasugai Aichi Japan;

    Osaka Yakin Kogyou Co Ltd Powder Proc Dept AM &

    Med Promot Sect Osaka Japan;

    Osaka Med Coll Div Life Sci Anat &

    Cell Biol Osaka Japan;

    Osaka Med Coll Div Med Funct &

    Morphol Sensor Organ Dent &

    Oral 2-7 Daigaku Machi Takatsuki Osaka 5698686 Japan;

    Osaka Med Coll Div Med Funct &

    Morphol Sensor Organ Dent &

    Oral 2-7 Daigaku Machi Takatsuki Osaka 5698686 Japan;

    Osaka Med Coll Div Med Funct &

    Morphol Sensor Organ Dent &

    Oral 2-7 Daigaku Machi Takatsuki Osaka 5698686 Japan;

    Kagoshima Univ Dept Restrat Dent &

    Endodontol Res Field Dent Med &

    Dent Sci Area Res &

    Educ Assembly Kagoshima Japan;

    Okayama Univ Grad Sch Med Dent &

    Pharmaceut Sci Dept Oral Pathol &

    Med Okayama Japan;

    Osaka Med Coll Div Med Funct &

    Morphol Sensor Organ Dent &

    Oral 2-7 Daigaku Machi Takatsuki Osaka 5698686 Japan;

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