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首页> 外文期刊>RSC Advances >Yiqi Fumai lyophilized injection attenuates doxorubicin-induced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis
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Yiqi Fumai lyophilized injection attenuates doxorubicin-induced cardiotoxicity, hepatotoxicity and nephrotoxicity in rats by inhibition of oxidative stress, inflammation and apoptosis

机译：Yiqi Fumai冻干注射通过抑制氧化应激，炎症和细胞凋亡抑制大鼠的多柔比蛋白诱导的心脏毒性，肝毒性和肾毒性

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摘要

Doxorubicin (DOX) is one of the most effective antineoplastic drugs, however, its organ toxicity inhibits the clinical utility. This study was aimed at investigating the protective effects of Yiqi Fumai lyophilized injection (YQFM) against DOX-induced tissue injury and exploring the mechanisms which mediated reactive oxygen species (ROS), inflammation and apoptosis. The experiment was as follows: rats were subjected to an intraperitoneal injection (i.p.) of YQFM (0.481 g kg(-1), i.p.) for 12 days; DOX (5 mg kg(-1), i.p.) was administered on the 4th, 8th and 12th days to achieve a cumulative dose of 15 mg kg(-1). Pretreatment of YQFM significantly ameliorated intracellular damage and dysfunction of the heart, liver and kidneys via decreasing activities of injury indexes. The levels of lipid peroxidation and glutathione depletion were clearly reduced following YQFM pretreatment, meanwhile the activities of glutathione peroxidase, superoxide dismutase, and catalase were elevated. Additionally administering YQFM could mitigate the cardiotoxicity, hepatotoxicity and nephrotoxicity via reducing levels of inflammatory factors and decreasing apoptosis. Accordingly, this study indicated that YQFM attenuated DOX-induced toxicity by ameliorating organ function, decreasing ROS production, and preventing excessive inflammation and apoptosis.
机译：多柔比星（DOX）是最有效的抗肿瘤药物之一，然而，其器官毒性抑制了临床效用。本研究旨在调查益气FumaI冻干注射（YQFM）对DOX诱导的组织损伤的保护作用，并探索介导反应性氧（ROS），炎症和凋亡的机制。实验如下：将大鼠腹腔注射（I.P.）的YQFM（0.481g kg（-1），I.p.）进行12天; DOX（5mg kg（-1），i.p.）在第4天，第8天和第12天施用，以实现15mg kg（-1）的累积剂量。通过降低损伤指数的活动，YQFM的预处理显着改善心脏，肝和肾功能障碍的细胞内损伤和功能障碍。在YQFM预处理后明显降低了脂质过氧化和谷胱甘肽耗尽的水平，同时谷胱甘肽过氧化物酶，超氧化物歧化酶和过氧化氢酶的活性升高。另外施用YQFM可以通过降低炎症因子的水平和降低细胞凋亡来减轻心脏毒性，肝毒性和肾毒性。因此，本研究表明，YQFM通过改善器官功能，降低ROS生产和预防过度炎症和细胞凋亡，YQFM衰减DOX诱导的毒性。

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  • 来源
    《RSC Advances》 |2018年第71期|共18页
  • 作者

    Gu Yue; Ju Aichun; Jiang Bingjie; Zhang Jingze; Man Shuli; Liu Changxiao; Gao Wenyuan;

  • 作者单位

    Tianjin Univ Sch Pharmaceut Sci &

    Technol Tianjin Key Lab Modern Drug Delivery &

    High Effie Weijin Rd Tianjin 300072 Peoples R China;

    Tasly Pride Pharmaceut Co Ltd Tianjin 300410 Peoples R China;

    Tianjin Univ Sch Pharmaceut Sci &

    Technol Tianjin Key Lab Modern Drug Delivery &

    High Effie Weijin Rd Tianjin 300072 Peoples R China;

    Logist Univ Chinese Peoples Armed Police Forces Dept Pharm Tianjin 300309 Peoples R China;

    Tianjin Univ Sci &

    Technol Coll Biotechnol State Key Lab Food Nutr &

    Safety Tianjin 300457 Peoples R China;

    State Key Labs Pharmacodynam &

    Pharmacokinet Tianjin 300193 Peoples R China;

    Tianjin Univ Sch Pharmaceut Sci &

    Technol Tianjin Key Lab Modern Drug Delivery &

    High Effie Weijin Rd Tianjin 300072 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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