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Gut microbiota as important modulator of metabolism in health and disease

机译：肠道microbiota作为健康和疾病中新陈代谢的重要调节剂

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摘要

The human gastrointestinal tract colonizes a large number of microbial microflora, forms a host-microbiota co-metabolism structure with the host to participate in various metabolic processes in the human body, and plays a major role in the host immune response. In addition, the dysbiosis of intestinal microbial homeostasis is closely related to many diseases. Thus, an in-depth understanding of the relationship between them is of importance for disease pathogenesis, prevention and treatment. The combined use of metagenomics, transcriptomics, proteomics and metabolomics techniques for the analysis of gut microbiota can reveal the relationship between microbiota and the host in many ways, which has become a hot topic of analysis in recent years. This review describes the mechanism of co-metabolites in host health, including short-chain fatty acids (SCFA) and bile acid metabolism. The metabolic role of gut microbiota in obesity, liver diseases, gastrointestinal diseases and other diseases is also summarized, and the research methods for multi-omics combined application on gut microbiota are summarized. According to the studies of the interaction mechanism between gut microbiota and the host, we have a better understanding of the use of intestinal microflora in the treatment of related diseases. It is hoped that the gut microbiota can be utilized to maintain human health, providing a reference for future research.
机译：人胃肠道殖民化大量微生物微生物群，与宿主形成宿主微生物的共代谢结构，以参与人体中的各种代谢过程，并在宿主免疫应答中发挥重要作用。此外，肠道微生物稳态的脱敏与许多疾病密切相关。因此，对它们之间的关系的深入理解是对疾病发病，预防和治疗的重要性。用于分析Gut Microbiota分析的组合使用Metagenomics，转录组，蛋白质组学和代谢组科技术可以在许多方面揭示微生物群和宿主之间的关系，这已成为近年来分析的热门话题。该综述描述了宿主健康中共代谢物的机制，包括短链脂肪酸（SCFA）和胆汁酸代谢。还总结了肠道微生物症在肥胖，肝脏疾病，胃肠疾病和其他疾病中的代谢作用，总结了对肠道微生物群的多OMICS联合应用的研究方法。根据Gut Microbiota与宿主之间的相互作用机制的研究，我们更好地了解在治疗相关疾病中使用肠道微生物。希望肠道微生物群可用于维持人类健康，为未来的研究提供参考。

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  • 来源
    《RSC Advances》 |2018年第74期|共10页
  • 作者

    Wang Xiang-qian; Zhang Ai-hua; Miao Jian-hua; Sun Hui; Yan Guang-li; Wu Fang-fang; Wang Xi-jun;

  • 作者单位

    Natl Engn Lab Dev Southwestern Endangered Med Mat Guangxi Bot Garden Med Plant Nanning Guangxi Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Lab Metab Chinmed Res Ctr State Adm TCM Dept Pharmaceut Ana Natl Chinmed Res Ctr Sino Amer Chinmed Technol Co Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Natl Engn Lab Dev Southwestern Endangered Med Mat Guangxi Bot Garden Med Plant Nanning Guangxi Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Lab Metab Chinmed Res Ctr State Adm TCM Dept Pharmaceut Ana Natl Chinmed Res Ctr Sino Amer Chinmed Technol Co Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Natl TCM Key Lab Serum Pharmacochem Lab Metab Chinmed Res Ctr State Adm TCM Dept Pharmaceut Ana Natl Chinmed Res Ctr Sino Amer Chinmed Technol Co Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Natl Engn Lab Dev Southwestern Endangered Med Mat Guangxi Bot Garden Med Plant Nanning Guangxi Peoples R China;

    Natl Engn Lab Dev Southwestern Endangered Med Mat Guangxi Bot Garden Med Plant Nanning Guangxi Peoples R China;

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