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Construction of a quaternary ammonium salt platform with different alkyl groups for antibacterial and biosensor applications

机译：用不同烷基的季铵盐平台构建抗菌和生物传感器应用

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摘要

An electrochemical platform was designed using biocompatible quaternary ammonium salts containing alkyl groups with different chain lengths as electrode materials for visible protein immobilization on a glassy carbon (GC) electrode. The electrode was constructed using a simple self-assembly method relying on the electrostatic interaction between negatively charged hemoglobin (Hb) and positively charged quaternary ammonium materials. The Hb/quaternary ammonium salts/GC assembly exhibited excellent catalytic and electrochemical activities. Additionally, the structure-function properties of the quaternary ammonium salts on the electrochemical behavior of Hb was systematically investigated for various alkyl chain lengths between monomer and polymeric structures. Meanwhile, the corresponding bactericidal activities of the monomers and related polymers were evaluated by determining the minimum bactericidal concentration (MBC), minimum inhibitory concentration (MIC), and inhibitory zone diameters against bacteria. The results of these studies demonstrated that the quaternary ammonium monomers not only immobilized more proteins, but also displayed better antibacterial activity as alkyl chain length increased. Moreover, polymers possessed higher antimicrobial activities than their monomeric counterparts. However, the efficiency of the direct electron transfer process and the antibacterial properties of long-chain polymers were limited because they were prone to aggregation and blistering. In summary, the present results provide convenient access to direct electrochemistry using an immobilized redox protein. Furthermore, the potential to use the obtained materials in the construction of third-generation electrochemical biosensors was evaluated.
机译：使用含有不同链长的烷基的生物相容性季铵盐设计了一种电化学平台，作为用于玻碳（GC）电极上可见蛋白质固定的电极材料。使用简单的自组装方法构建电极，依赖于带负电荷的血红蛋白（HB）与带正电荷的季铵材料之间的静电相互作用。 HB /季铵盐/ GC组件表现出优异的催化和电化学活性。另外，对单体和聚合物结构之间的各种烷基链长度系统地研究了季铵盐对Hb电化学行为的结构功能性质。同时，通过确定最小杀菌浓度（MBC），最小抑制浓度（MIC）和抑制细菌的抑制区直径来评价单体和相关聚合物的相应杀菌活性。这些研究的结果表明，季铵单体不仅固定更多的蛋白质，而且还显示出更好的抗菌活性，因为烷基链长度增加。此外，聚合物具有比单体对应物更高的抗微生物活性。然而，直接电子转移过程的效率和长链聚合物的抗菌性质受到限制，因为它们易于聚集和起泡。总之，目前的结果提供了使用固定化的氧化还原蛋白的直接电化学的方便进入。此外，评估了在构建第三代电化学生物传感器的结构中使用所得材料的可能性。

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  • 来源
    《RSC Advances》 |2018年第6期|共9页
  • 作者

    Lv Xue; Liu Chuang; Song Shixin; Qiao Yun; Hu Yuanjiao; Li Pengfei; Li Zhaokun; Sun Shulin;

  • 作者单位

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

    Beijing Acad Printing &

    Packaging Ind Technol Beijing Inst Graph Commun Beijing 102600 Peoples R China;

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

    Changchun Univ Technol Changchun 130012 Jilin Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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