• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Magnetic carbon nanotubes for self-regulating temperature hyperthermia
【24h】

Magnetic carbon nanotubes for self-regulating temperature hyperthermia

机译：用于自调节温度热疗的磁性碳纳米管

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Magnetic hyperthermia can enhance the anti-tumor effects of chemotherapy. As carbon nanotubes are ideal drug carriers for chemotherapy, their combination with magnetic nanoparticles provides a novel chance for multi-modal thermo-chemotherapy. Most related work focuses on attaching Fe3O4 nanoparticles on carbon nanotubes, however the hyperthermia temperature for this combination can not be self-regulated due to the high Curie temperature of Fe3O4. In this work, magnetic Zn0.54Co0.46Cr0.6Fe1.4O4 nanoparticles with low Curie temperature were attached onto carbon nanotubes to obtain the magnetic carbon nanotubes. The morphology, formation mechanism, magnetic properties, heat generation ability and cytotoxicity of the magnetic carbon nanotubes were investigated. These magnetic carbon nanotubes show a Curie temperature of 43 degrees C and a self-regulating temperature at 42.7 degrees C under clinically applied magnetic field conditions (frequency: 100 kHz, intensity: 200 Oe). The evaluation of in vitro cytotoxicity suggests no obvious toxicity effects under the concentrations of 6.25 mu g ml(-1) to 100 mu g ml(-1). This study proposed a methodology for the bespoke synthesis of magnetic carbon nanotubes with a low Curie temperature for self-regulating magnetic hyperthermia, which may be used for further research on loading drugs for multi-modal cancer therapy.
机译：磁体热疗可以增强化学疗法的抗肿瘤作用。由于碳纳米管是用于化疗的理想药物载体，它们与磁性纳米粒子的组合为多种模式热化疗提供了新的机会。大多数相关工作侧重于将Fe3O4纳米颗粒上附着在碳纳米管上，然而，由于Fe3O4的高居里温度，这种组合的热疗温度不能自调节。在这项工作中，将具有低居里温度的磁性Zn0.54CO0.46CR0.6FE1.4O4纳米颗粒连接到碳纳米管上以获得磁性碳纳米管。研究了磁性碳纳米管的形态，形成机理，磁性，发热能力和细胞毒性。这些磁性碳纳米管在临床施加的磁场条件（频率：100kHz，强度：200 OE）下，静脉温度为43℃，42.7℃下的自调节温度。体外细胞毒性的评价表明，在6.25μgmm（-1）至100μg（-1）的浓度下没有明显的毒性作用。该研究提出了对具有低居里温度的磁性碳纳米管的定制合成的方法，用于自调节磁体温热，这可用于进一步研究用于多种血型癌症治疗的药物。

著录项

  • 来源
    《RSC Advances》 |2018年第22期|共7页
  • 作者

    Zuo Xudong; Wu Chengwei; Zhang Wei; Gao Wei;

  • 作者单位

    Dalian Univ Technol Dept Engn Mech State Key Lab Struct Anal Ind Equipment Dalian 116024 Peoples R China;

    Dalian Univ Technol Dept Engn Mech State Key Lab Struct Anal Ind Equipment Dalian 116024 Peoples R China;

    Dalian Univ Technol Dept Engn Mech State Key Lab Struct Anal Ind Equipment Dalian 116024 Peoples R China;

    Univ Auckland Dept Chem &

    Mat Engn Auckland 1142 New Zealand;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号