Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

Mohamed H. A.; Khuphe M.; Boardman S. J.; Shepherd S.; Phillips R. M.; Thornton P. D.; Willans C. E.

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Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

机译：聚合物包封抗癌银 - 正杂环碳烯络合物

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Amphiphilic block copolymers have been developed for the encapsulation of organometallic drugs. silver-N-heterocyclic carbene complexes have shown significant promise as anticancer and antibacterial compounds, and have been studied as the payload in these carriers. Simple modification of the N-heterocyclic carbene ligand structure enables solubility properties and interaction with the polymer to be tuned.

机译：已经开发了两亲嵌段共聚物用于封装有机金属药物。银 - 杂环卡宾复合物具有显着的希望作为抗癌和抗菌化合物，并已被研究作为这些载体中的有效载荷。 N-杂环配体结构的简单改性能够使溶解性和与聚合物进行调节的相互作用。

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《RSC Advances》 |2018年第19期|共4页
作者
Mohamed H. A.; Khuphe M.; Boardman S. J.; Shepherd S.; Phillips R. M.; Thornton P. D.; Willans C. E.;
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Univ Leeds Sch Chem Woodhouse Lane Leeds LS2 9JT W Yorkshire England;

Univ Leeds Sch Chem Woodhouse Lane Leeds LS2 9JT W Yorkshire England;

Univ Leeds Sch Chem Woodhouse Lane Leeds LS2 9JT W Yorkshire England;

Univ Huddersfield Dept Pharm Huddersfield HD1 3DH W Yorkshire England;

Univ Huddersfield Dept Pharm Huddersfield HD1 3DH W Yorkshire England;

Univ Leeds Sch Chem Woodhouse Lane Leeds LS2 9JT W Yorkshire England;

Univ Leeds Sch Chem Woodhouse Lane Leeds LS2 9JT W Yorkshire England;

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正文语种 eng
中图分类化学;
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1. Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes [J] . Mohamed H. A., Khuphe M., Boardman S. J., RSC Advances . 2018,第19期

机译：聚合物包封抗癌银 - 正杂环碳烯络合物
2. Anticancer Activity of Silver-N-Heterocyclic Carbene Complexes: Caspase-Independent Induction of Apoptosis via Mitochondrial Apoptosis-lnducing Factor (AIF) [J] . Laure Eloy, Anne-Sophie Jarrousse, Marie-Laure Teyssot ChemMedChem . 2012,第5期

机译：银-N-杂环碳烯复合物的抗癌活性：通过线粒体细胞凋亡诱导因子（AIF）的胱天蛋白酶独立诱导的细胞凋亡。
3. Nanoparticle encapsulated silver carbene complexes and their antimicrobial and anticancer properties: A perspective [J] . Youngs W.J., Knapp A.R., Wagers P.O., Dalton transactions: An international journal of inorganic chemistry . 2012,第2期

机译：纳米粒子包封的卡宾银配合物及其抗菌和抗癌特性
4. N-Heterocyclic Carbene Chelated Metal Complexes as Polymerization Catalysts [C] . Amer A. El-Batta Materials Research Society Symposium on Extreme Environments . 2013

机译：N-杂环卡内螯合金属配合物作为聚合催化剂
5. Encapsulating N-Heterocyclic Carbene Complexes into Biodegradable Nanoparticles and the Antimicrobial and Antitumor Effects [D] . Robishaw, Nikki K. 2018

机译：将N-杂环碳烯复合物包封到可生物降解的纳米粒子中及其抗菌和抗肿瘤作用
6. Imidazole and Benzimidazole Modified Half-Sandwich IridiumIIIN-Heterocyclic Carbene Complexes: Synthesis Anticancer Application and Organelle Targeting [O] . Xicheng Liu, Yali Han, Xingxing Ge, 2020

机译：咪唑和苯并咪唑改性的半三明治铱IIIIN-杂环碳烯配合物：合成抗癌应用和细胞器靶向。
7. Polymer encapsulation of anticancer silver–N-heterocyclic carbene complexes [O] . H. A. Mohamed, M. Khuphe, S. J. Boardman, 2018

机译：聚合物包封抗癌银 - 正杂环碳烯络合物
8. Highly Reduced Carbene Complexes: Formation of an Alkoxymalonate by Coupling of Carbon Dioxide with the Nucleophilic Carbene in (Cr(CO4)=C(OMe)PH)2-. [R] . Lee, S., Cooper, J. 1989

机译：高度还原的卡宾配合物：通过二氧化碳与亲核卡宾的偶联形成烷氧基丙二酸酯（Cr（CO4）= C（Ome）pH）2-。

Polymer encapsulation of anticancer silver-N-heterocyclic carbene complexes

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