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The digestibility of hydrothermally-treated bovine serum albumin glycated by glyoxal

机译：乙二醛糖化水热处理的牛血清白蛋白的消化率

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摘要

The digestion of dietary advanced glycation end products (AGEs) largely determines their absorption in humans. To help elucidate the health effects of dietary AGEs, changes in the digestive behavior of bovine serum albumin (BSA, dietary protein) caused by glycation derived from glyoxal (GO, an important precursor of AGEs) in a simulated food heating system have been investigated. The hydrothermal aggregation of BSA was suppressed by GO derived glycation, generating glycated aggregates of loose and branched structures, according to dynamic light scattering (DLS), circular dichroism (CD) spectroscopy, free sulfhydryl group, transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS) results. Analysis of protein digests showed that glycation reduced the gastric and gastrointestinal digestibility of BSA and the bioavailability of all seven detected amino acids. A comparative analysis of the distribution of CML and lysine in glycated BSA digests with different molecular weights showed that carboxymethylation directly blocked the action of proteases on Lys residues.
机译：饮食中晚期糖基化终产物（AGEs）的消化在很大程度上决定了他们在人体内的吸收。为了帮助阐明饮食青睐健康的影响，造成从乙二醛（GO，年龄的重要前体）以模拟食品加热系统得到的糖化牛血清白蛋白（BSA，膳食蛋白质）的消化行为的变化进行了研究。 BSA的水热聚合物通过GO抑制衍生糖化，生成糖化松散和支化结构的聚集体，根据动态光散射（DLS），圆二色性（CD）光谱法，游离的巯基，透射电子显微镜（TEM）和小角X射线散射（SAXS）的结果。蛋白质消化的分析表明，糖化减少BSA的胃和胃肠道消化和所有七的生物利用度检测氨基酸。 CML的在具有不同分子量的糖化BSA消化的分布和赖氨酸的比较分析表明，羧甲基化直接阻断蛋白酶的上个Lys残基的作用。

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  • 来源
    《RSC Advances》 |2018年第63期|共8页
  • 作者

    Su Guoying; Li Lin; Zhao Di; Li Bing; Zhang Xia;

  • 作者单位

    South China Univ Technol Sch Food Sci &

    Engn 381 Wushan Rd Guangzhou 510640 Guangdong Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn 381 Wushan Rd Guangzhou 510640 Guangdong Peoples R China;

    Nanjing Agr Univ Key Lab Meat Proc &

    Qual Control Jiangsu Collaborat Innovat Ctr Meat Prod &

    Proc Q Key Lab Meat Prod Proc MOE MOA Nanjing 210095 Jiangsu Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn 381 Wushan Rd Guangzhou 510640 Guangdong Peoples R China;

    South China Univ Technol Sch Food Sci &

    Engn 381 Wushan Rd Guangzhou 510640 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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