• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >A GSH- responsive nanophotosensitizer for efficient photodynamic therapy
【24h】

A GSH- responsive nanophotosensitizer for efficient photodynamic therapy

机译：一种高效光动力疗效的GSH-响应纳米光敏化剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Photodynamic therapy (PDT) is a promising cancer treatment modality, which depends on the reactive oxygen species (ROS) generated by a photosensitizer to kill cancer cells. The lack of selectivity and the over-production of glutathione (GSH) in cancer cells are the two major challenges for efficient and safe cancer PDT because they can cause harm to normal tissues and eliminate ROS in cancer cells. Herein, we report a GSH-responsive nanophotosensitizer based on CoOOH nanosheets for PDT of cancer. The nanophotosensitizer shows negligible photo-toxicity toward normal cells because of the quenching effect between CoOOH and photosensitizer Ce6. In the presence of overexpressed GSH, Ce6 molecules can be released into cancer cells because of GSH induced degradation of CoOOH nanosheets. In vivo experiments demonstrated that the tumor growth was efficiently inhibited by the CoOOH-based PDT strategy. The current nanophotosensitizer represents a promising smart platform to synergistically improve the therapeutic index and safety of PDT.
机译：光动力疗法（PDT）是一种有前途的癌症治疗方式，这取决于光敏剂产生的反应性氧物质（ROS）以杀死癌细胞。癌细胞中缺乏选择性和谷胱甘肽（GSH）的过度生产是高效和安全的癌症PDT的两个主要挑战，因为它们可能对正常组织造成伤害并消除癌细胞中的ROS。在此，我们报告了基于CoOOH纳米片的GSH响应性纳米溶胶蛋白，用于癌症PDT。由于CooOH和光敏剂CE6之间的猝灭效应，纳米光溶剂显示出朝向正常细胞的可忽略不计的照片毒性。在存在过表达GSH的情况下，由于GSH诱导的CoOOH纳米片的降解，CE6分子可以释放到癌细胞中。体内实验表明，基于COOOH的PDT策略有效地抑制了肿瘤生长。目前的纳米光溶胶代表了一个有前途的智能平台，以协同改善PDT的治疗指标和安全性。

著录项

  • 来源
    《RSC Advances》 |2018年第74期|共6页
  • 作者

    Pan Wei; Shi Mingwan; Li Yanhua; Chen Yuanyuan; Li Na; Tang Bo;

  • 作者单位

    Shandong Normal Univ Coll Chem Chem Engn &

    Mat Sci Collaborat Innovat Ctr Functionalized Probes Chem Inst Mol &

    Nano Sci Key Lab Mol &

    Nano Probes Min Jinan 250014 Shandong Peoples R China;

    Shandong Normal Univ Coll Chem Chem Engn &

    Mat Sci Collaborat Innovat Ctr Functionalized Probes Chem Inst Mol &

    Nano Sci Key Lab Mol &

    Nano Probes Min Jinan 250014 Shandong Peoples R China;

    Shandong Normal Univ Coll Chem Chem Engn &

    Mat Sci Collaborat Innovat Ctr Functionalized Probes Chem Inst Mol &

    Nano Sci Key Lab Mol &

    Nano Probes Min Jinan 250014 Shandong Peoples R China;

    Shandong Normal Univ Coll Chem Chem Engn &

    Mat Sci Collaborat Innovat Ctr Functionalized Probes Chem Inst Mol &

    Nano Sci Key Lab Mol &

    Nano Probes Min Jinan 250014 Shandong Peoples R China;

    Shandong Normal Univ Coll Chem Chem Engn &

    Mat Sci Collaborat Innovat Ctr Functionalized Probes Chem Inst Mol &

    Nano Sci Key Lab Mol &

    Nano Probes Min Jinan 250014 Shandong Peoples R China;

    Shandong Normal Univ Coll Chem Chem Engn &

    Mat Sci Collaborat Innovat Ctr Functionalized Probes Chem Inst Mol &

    Nano Sci Key Lab Mol &

    Nano Probes Min Jinan 250014 Shandong Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号