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首页> 外文期刊>RSC Advances >Benzyl salicylate from the stems and stem barks of Cornus walteri as a nephroprotective agent against cisplatin-induced apoptotic cell death in LLC-PK1 cells
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Benzyl salicylate from the stems and stem barks of Cornus walteri as a nephroprotective agent against cisplatin-induced apoptotic cell death in LLC-PK1 cells

机译：来自玉米氏玉米氏茎和茎的苄基和茎鲨在LLC-PK1细胞中作为针对顺铂诱导的凋亡细胞死亡的肾脏保护剂

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摘要

Nephrotoxicity currently plagues the therapeutic use of cisplatin. Its major side effects are predominantly associated with renal tubular cell apoptosis. In this study, we examined the potential nephroprotective constituents from C. walteri that can exert effects against cisplatin-induced oxidative stress and apoptosis in renal tubular epithelial (LLC-PK1) cells. Phytochemical investigation of the MeOH extract of the stems and stem barks of C. walteri led to the isolation of the potential nephroprotective constituents (1-15). Among the isolates, treatment with benzyl salicylate (BS) (15) (50 and 100 mu M) significantly attenuated LLC-PK1 cell apoptosis and potently blocked cisplatin-induced nuclei condensation, intracellular ROS generation, and apoptosis, as indicated by Hoechst 33342 and H(2)DCFDA staining. Furthermore, the expression of apoptosis-related proteins such as MAPK, Bax/Bcl-2 protein ratio, and cleaved caspase-9 and -3, were significantly decreased by BS. These findings provide that benzyl salicylate can be a nephroprotective agent against cisplatin-induced oxidative stress and apoptosis.
机译：肾毒性目前困扰着顺铂的治疗用途。其主要副作用主要与肾小管细胞凋亡相关。在这项研究中，我们研究了来自C.Walteri的潜在的肾脏反应成分，可以对肾小管上皮（LLC-PK1）细胞中的顺铂诱导的氧化应激和凋亡产生影响。 C.Walteri茎和茎吠茎的MeOH提取物的植物化学研究导致潜在肾外产成分的分离（1-15）。在分离物中，用苄基（BS）（15）（15）（50和100μm）处理显着减弱LLC-PK1细胞凋亡，并且易于阻断的顺铂诱导的核缩合，细胞内ROS生成和凋亡，如Hoechst 33342所示H（2）DCFDA染色。此外，BS，诸如MAPK，BCL-2蛋白比和切割的Caspase-9和-3的凋亡相关蛋白质的表达显着降低。这些发现提供了苄基水杨酸苄酯可以是针对顺铂诱导的氧化胁迫和凋亡的肾反应剂。

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  • 来源
    《RSC Advances》 |2020年第10期|共8页
  • 作者

    Lee Dahae; Lee Seoung Rak; Kang Ki Sung; Kim Ki Hyun;

  • 作者单位

    Sungkyunkwan Univ Sch Pharm Suwon 440746 South Korea;

    Sungkyunkwan Univ Sch Pharm Suwon 440746 South Korea;

    Gachon Univ Coll Korean Med Seongnam 13120 South Korea;

    Sungkyunkwan Univ Sch Pharm Suwon 440746 South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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