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首页> 外文期刊>RSC Advances >Fabrication of a paper strip for facile and rapid detection of bovine viral diarrhea virusviasignal enhancement by copper polyhedral nanoshells
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Fabrication of a paper strip for facile and rapid detection of bovine viral diarrhea virusviasignal enhancement by copper polyhedral nanoshells

机译：通过铜多面体纳米粒子的储备和快速检测纸质条带的纸质条带的制作型牛肝菌腹泻病毒增强

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摘要

The detection of bovine viral diarrhea virus (BVDV), which is a pathogen inducing fatal gastrointestinal disease in cattle, is becoming a momentous issue in the livestock farm. In that, BVDV is related to inapparent infection and various diseases with high transmissibility; it has also led to considerable economic losses. In this study, a simple dot-blotting method was devised to construct a rapid screening system for BVDV. Based on the BVDV-specific bioreceptors, it was anchored on the gold nanoparticles (AuNPs) to generate the seeding sites for signaling; then the signals were amplified by adopting the overgrowth of copper nano-polyhedral shells on AuNPs. The developed detection system shows a low detection limit of 4.4 copies per mL, and even this could be distinguished with naked eyes. These results indicate that the designed nanobiosensor possesses not only high sensitivity and selectivity but also potential usage on a point-of-care testing platform for BVDV.
机译：牛病毒腹泻病毒（BVDV）的检测，即养牛场诱导致命胃肠疾病的病原体正在成为牲畜农场的重要问题。 在此，BVDV与具有不良感染和具有高透射性的各种疾病有关; 它还导致了相当大的经济损失。 在该研究中，设计了一种简单的点印迹方法，构建了BVDV的快速筛选系统。 基于BVDV特异性生物受体，它锚定在金纳米颗粒（AUNP）上以产生用于信号传导的播种位点; 然后通过在肛周上采用铜纳米多面体壳的过度生长来扩增信号。 开发的检测系统显示每mL的4.4拷贝的低检测限度，甚至可以用肉眼区分。 这些结果表明，设计的纳米极性传感器不仅具有高灵敏度和选择性，而且具有对BVDV的护理点测试平台的潜在用途。

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  • 来源
    《RSC Advances》 |2020年第50期|共6页
  • 作者

    Kim Min Woo; Park Hong-Je; Park Chan Yeong; Kim Ji Hong; Cho Chae Hwan; Le Minh Tu Phan; Park Jong Pil; Kailasa Suresh Kumar; Lee Chi-Ho; Park Tae Jung;

  • 作者单位

    Chung Ang Univ Dept Chem Res Inst Chem Bio Diagnost Technol 84 Heukseok Ro Seoul 06974 South Korea;

    Medexx Co Ltd R&

    D Ctr 5F B Korea Bio Pk Seongnam Si 13488 Gyeonggi Do South Korea;

    Chung Ang Univ Dept Chem Res Inst Chem Bio Diagnost Technol 84 Heukseok Ro Seoul 06974 South Korea;

    Chung Ang Univ Dept Food Sci &

    Biotechnol Ansung 17546 South Korea;

    Chung Ang Univ Dept Food Sci &

    Biotechnol Ansung 17546 South Korea;

    Chung Ang Univ Dept Chem Res Inst Chem Bio Diagnost Technol 84 Heukseok Ro Seoul 06974 South Korea;

    Chung Ang Univ Dept Food Sci &

    Biotechnol Ansung 17546 South Korea;

    Sardar Vallabhbhai Natl Inst Technol Dept Appl Chem Surat 395007 Gujarat India;

    Konkuk Univ Dept Food Sci &

    Biotechnol Anim Resources 120 Neungdong Ro Seoul 05029 South Korea;

    Chung Ang Univ Dept Chem Res Inst Chem Bio Diagnost Technol 84 Heukseok Ro Seoul 06974 South Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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