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Therapeutic lipid-coated hybrid nanoparticles against bacterial infections

机译：治疗性脂质涂覆的细菌感染杂交纳米粒子

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摘要

One of the most important health concerns in society is the development of pathogen-causing nosocomial infections. Since the first discovery of antibiotics, bacterial infections have been highly treatable. However, with evolution and the nondiscretionary usage of antibiotics, pathogens have also found new ways to survive the onslaught of antibiotics by surviving intracellularly or through the formation of obstinate biofilms, and through these, the outcomes of regular antibiotic treatments may now be unsatisfactory. Lipid-coated hybrid nanoparticles (LCHNPs) are the next-generation core-shell structured nanodelivery system, where an inorganic or organic core, loaded with antimicrobials, is enveloped by lipid layers. This core-shell structure, with multifarious decorations, not only improves the loading capabilities of therapeutics but also has the potential to improve therapeutic delivery, especially for targeting biofilm-based and intracellular bacterial infections. Although there has been significant interest in the development of LCHNPs, they have yet to be widely exploited for bacterial infections. In this review, we will provide an overview on the latest development of LCHNPs and the various approaches in synthesizing this nano-delivery system. In addition, a discussion on future perspectives of LCHNPs, in combination with other novel anti-bacterial technologies, will be provided towards the end of this review.
机译：社会中最重要的健康问题之一是发育病原因的医院感染。由于第一次发现抗生素，细菌感染是可观的。然而，随着抗生素的进化和不受欢迎的使用，病原体还发现通过细胞内或通过形成顽固的生物膜来生存来生存抗生素的新方法，并通过这些，常规抗生素治疗的结果现在可能不令人满意。涂覆的杂交纳米颗粒（LCHNP）是下一代核 - 壳结构纳米型纳米型交货系统，其中无机或有机核心含有抗微生物的核心被脂层包裹。这种核心壳结构，具有多种装饰品，不仅提高了治疗剂的负载能力，而且还具有改善治疗递送的潜力，特别是对于靶向生物膜和细胞内细菌感染。虽然对LCHNP的发展有重大兴趣，但他们尚未被广泛利用细菌感染。在本次审查中，我们将概述LCHNP的最新开发和合成该纳米输送系统的各种方法。此外，将在本次审查结束时提供关于LCHNPS的未来视角，与其他新型抗细菌技术相结合。

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  • 来源
    《RSC Advances》 |2020年第14期|共21页
  • 作者

    Jiang Lai; Lee Hiang Wee; Loo Say Chye Joachim;

  • 作者单位

    Nanyang Technol Univ Sch Mat Sci Sc Engn 50 Nanyang Ave Singapore 639798 Singapore;

    Nanyang Technol Univ Sch Mat Sci Sc Engn 50 Nanyang Ave Singapore 639798 Singapore;

    Nanyang Technol Univ Sch Mat Sci Sc Engn 50 Nanyang Ave Singapore 639798 Singapore;

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  • 正文语种 eng
  • 中图分类 化学;
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