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首页> 外文期刊>RSC Advances >Deepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicles
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Deepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicles

机译：深化进入聚（环氧丙烷） - 嵌段 - 聚（缩水甘油）合成和自组装的洞察：胶束，蠕虫和囊泡

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摘要

Aqueous self-assembly of amphiphilic block copolymers is studied extensively for biomedical applications like drug delivery and nanoreactors. The commonly used hydrophilic block poly(ethylene oxide) (PEO), however, suffers from several drawbacks. As a potent alternative, poly(glycidol) (PG) has gained increasing interest, benefiting from its easy synthesis, high biocompatibility and flexibility as well as enhanced functionality compared to PEO. In this study, we present a quick and well-controlled synthesis of poly(butylene oxide)-block-poly(glycidol) (PBO-b-PG) amphiphilic diblock copolymers together with a straight-forward self-assembly protocol. Depending on the hydrophilic mass fraction of the copolymer, nanoscopic micelles, worms and polymersomes were formed as well as microscopic giant unilamellar vesicles. The particles were analysed regarding their size and shape, using dynamic and static light scattering, TEM and Cryo-TEM imaging as well as confocal laser scanning microscopy. We have discovered a strong dependence of the formed morphology on the self-assembly method and show that only solvent exchange leads to the formation of homogenous phases. Thus, a variety of different structures can be obtained from a highly flexible copolymer, justifying a potential use in biomedical applications.
机译：两亲性嵌段共聚物的水性自组装像药物递送和纳米反应器的生物医学应用广泛的研究。常用的亲水性嵌段聚（环氧乙烷）（PEO），然而，有几个缺点。作为有效替代方案中，聚（缩水甘油）（PG）已经获得了越来越多的关注，其从合成容易，良好的生物相容性和柔性以及增强的功能相比，PEO中受益。在这项研究中，我们提出的聚（环氧丁烷）的快速和良好受控的合成 - 嵌段 - 聚（缩水甘油）（PBO-B-PG）具有直进自组装协议一起两亲性嵌段共聚物。取决于共聚物的亲水性质量分数，形成纳米级的胶束，蠕虫和聚合物囊泡以及微观大单层囊泡。关于它们的尺寸和形状中的颗粒进行分析，使用动态和静态光散射，TEM和低温-TEM成像以及共焦激光扫描显微镜。我们已经发现了强烈的自组装法形成的形态的依赖性和表明，只有溶剂交换导致均匀的相的形成。因此，可以从一个高度灵活的共聚物能够获得各种不同的结构，证明在生物医学应用中的潜在用途。

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  • 来源
    《RSC Advances》 |2020年第38期|共11页
  • 作者

    Wehr Riccardo; Gaitzsch Jens; Daubian Davy; Fodor Csaba; Meier Wolfgang;

  • 作者单位

    Univ Basel Dept Chem Mattenstr 24a BPR 1096 CH-4058 Basel Switzerland;

    Univ Basel Dept Chem Mattenstr 24a BPR 1096 CH-4058 Basel Switzerland;

    Univ Basel Dept Chem Mattenstr 24a BPR 1096 CH-4058 Basel Switzerland;

    Univ Basel Dept Chem Mattenstr 24a BPR 1096 CH-4058 Basel Switzerland;

    Univ Basel Dept Chem Mattenstr 24a BPR 1096 CH-4058 Basel Switzerland;

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  • 正文语种 eng
  • 中图分类 化学;
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