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Synthesis and properties of a temperature-sensitive hydrogel based on physical crosslinkingviastereocomplexation of PLLA-PDLA

机译：基于PLLA-PDLA物理交联剂的温度敏感水凝胶的合成与性能

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摘要

A synthetic route to amphiphilic conetwork (APCN) gels was developed and involved (1) a ring-opening polymerization (ROP) synthesis of the macromonomer HEMA-PLLA/PDLA, and (2) a radical polymerization of a stereocomplex of the synthesized macromonomers with P(MEO(2)MA-co-OEGMA) to form the APCN gels. The structure of the gel was successfully verified using X-ray diffraction. Thermal analysis and differential scanning calorimetry data showed that the thermal behaviors of the gels were greatly improved compared with that of polylactic acid (PLA). The mechanical properties of the gels were measured by using a dynamic viscometer, and the results indicated a greater mechanical strength before swelling than afterwards, and an increasing strength of the gels with increasing amount of PLA stereocomplex. Gels placed in different aqueous phases at different temperatures showed different swelling ratio (SR) values. Specifically, the SR gradually decreased as the temperature was increased, indicating a temperature sensitivity of the gels. In addition, the gels placed in the aqueous and organic phases presented as hydrogels and hydrophobic gels, respectively, and their SR values were relatively low. These results indicated the amphiphilic nature of the gel, and indicated great application prospects for the gel in biomedicine.
机译：开发和涉及到两亲菌属孔（APCN）凝胶的合成途径（1）长聚单体HEMA-PLLA / PDLA的开环聚合（ROP）合成，（2）与合成的大分子单体的立体络合物的自由基聚合P（Meo（2）MA-CO-OEGMA）形成APCN凝胶。使用X射线衍射成功验证凝胶的结构。热分析和差示扫描量热法显示，与聚乳酸（PLA）相比，凝胶的热行为大大提高。通过使用动态粘度计测量凝胶的机械性能，结果表明溶胀前的机械强度比之后的更大，以及随着PLA立体络合物量的增加而增加的凝胶强度。在不同温度下置于不同水相中的凝胶显示出不同的溶胀比（SR）值。具体地，随着温度的增加，Sr逐渐降低，表明凝胶的温度敏感性。另外，分别呈现为水凝胶和疏水凝胶的水性和有机相中的凝胶，并且它们的Sr值相对较低。这些结果表明了凝胶的两亲性质，并表明了生物医学中凝胶的巨大应用前景。

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  • 来源
    《RSC Advances》 |2020年第34期|共11页
  • 作者

    Shi Xiaoyu; Wu Jie; Wang Zhidan; Song Fei; Gao Wenli; Liu Shouxin;

  • 作者单位

    Shaanxi Normal Univ Key Lab Appl Surface &

    Colloid Chem Minist Educ Xian 710062 Peoples R China;

    Shaanxi Normal Univ Key Lab Appl Surface &

    Colloid Chem Minist Educ Xian 710062 Peoples R China;

    Shaanxi Normal Univ Key Lab Appl Surface &

    Colloid Chem Minist Educ Xian 710062 Peoples R China;

    Shaanxi Normal Univ Key Lab Appl Surface &

    Colloid Chem Minist Educ Xian 710062 Peoples R China;

    Shaanxi Normal Univ Key Lab Appl Surface &

    Colloid Chem Minist Educ Xian 710062 Peoples R China;

    Shaanxi Normal Univ Key Lab Appl Surface &

    Colloid Chem Minist Educ Xian 710062 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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