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首页> 外文期刊>RSC Advances >pH-sensitive CAP/SiO2 composite for efficient co-delivery of doxorubicin and siRNA to overcome multiple drug resistance
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pH-sensitive CAP/SiO2 composite for efficient co-delivery of doxorubicin and siRNA to overcome multiple drug resistance

机译：pH敏感盖/ SiO2复合材料，用于高效共递送多柔比星和siRNA，以克服多种耐药性

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摘要

Long-term administration of chemotherapeutic agents often leads to multiple drug resistance (MDR), which greatly impairs the treatment outcome. To overcome this problem, a biodegradable nanocarrier based on an acid-sensitive calcium phosphate/silica dioxide (CAP/SiO2) composite was constructed for the codelivery of drug and siRNA. Anticancer drug doxorubicin (DOX) was encapsulated into the composite scaffold by interacting with the exposed Ca2+ of CAP/SiO2 to achieve high drug loading (180 mu g mg(-1)). With further decoration of siRNA, the nanocarrier was applied to enhance the therapeutic efficacy by silencing MDR-relevant genes (P-gp) of DOX-resistance K562/ADR cancer cells. Benefiting from the intrinsic acid degradability of CAP/SiO2, the nanocomposite demonstrated pH-responsive release behavior, favoring drug/siRNA release within acidic endo-/lysosomes. Consequently, due to the drug and gene effects, this biodegradable nanomedicine demonstrated enhanced therapeutic efficiency, providing a novel strategy for cancer therapy.
机译：长期施用化学治疗剂通常导致多种耐药性（MDR），这极大地损害了治疗结果。为了克服该问题，构建了一种基于酸敏感磷酸钙/二氧化硅（Cap / SiO 2）复合材料的可生物降解的纳米载体用于药物和siRNA的编码递送。抗癌药物多柔比星（DOX）被封装到复合支架通过与CAP / SiO 2的暴露的Ca 2+相互作用以实现高的药物载量（180亩克毫克（-1））。利用siRNA的进一步装饰，纳米载体被扫描以增强DOx抗性K562 / ADR癌细胞的MDR相关基因（P-GP）来增强治疗效果。受益于帽/ SiO2的内在酸可降解性，纳米复合材料显示pH-响应释放行为，最有利于酸性内/溶酶体中的药物/ siRNA释放。因此，由于药物和基因效应，这种可生物降解的纳米医生证明了增强的治疗效率，为癌症治疗提供了新的策略。

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  • 来源
    《RSC Advances》 |2020年第8期|共7页
  • 作者

    Cai Zheng; Chen Yuezhu; Zhang Yingwen; He Zhimei; Wu Xiaoge; Jiang Li-Ping;

  • 作者单位

    Nanjing Univ State Key Lab Analyt Chem Life Sci Sch Chem &

    Chem Engn Nanjing 210023 Peoples R China;

    Nanjing Univ State Key Lab Analyt Chem Life Sci Sch Chem &

    Chem Engn Nanjing 210023 Peoples R China;

    Nanjing Univ State Key Lab Analyt Chem Life Sci Sch Chem &

    Chem Engn Nanjing 210023 Peoples R China;

    Nanjing Univ State Key Lab Analyt Chem Life Sci Sch Chem &

    Chem Engn Nanjing 210023 Peoples R China;

    Nanjing Univ State Key Lab Analyt Chem Life Sci Sch Chem &

    Chem Engn Nanjing 210023 Peoples R China;

    Nanjing Univ State Key Lab Analyt Chem Life Sci Sch Chem &

    Chem Engn Nanjing 210023 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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