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首页> 外文期刊>RSC Advances >Finely crafted quasi-core-shell gadolinium/layered double hydroxide hybrids for switching on/off bimodal CT/MRI contrasting nanodiagnostic platforms
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Finely crafted quasi-core-shell gadolinium/layered double hydroxide hybrids for switching on/off bimodal CT/MRI contrasting nanodiagnostic platforms

机译：精细制成的准核 - 壳钆/层状双氢氧化物杂交用于开关开/关双峰CT / MRI对比纳米杆状平台

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摘要

We successfully synthesized a size-controlled hybrid of layered double hydroxide (LDH) platelets and Gd(OH)(3) nanorods through the reverse micelle method. Under controlled synthetic conditions, the hybrid was developed to a quasi-core-shell structure, where the Gd(OH)(3) nanorods were covered by the LDH platelet assembly, and this was investigated by X-ray diffraction and high-resolution transmission electron microscopy. The zeta potential measurement for the hybrid revealed that Gd(OH)(3) was surrounded by LDH moieties. According to dynamic light scattering, the hydrodynamic radius of the hybrid was uniformly controlled under 150 nm, which was comparable to that of one Gd(OH)(3) nanorod surrounded by an LDH moiety. Thus, the obtained hybrid exhibited a maximum Hounsfield unit of 180 at a concentration of 5 mg mL(-1), implying its potential as a computed tomography contrast agent. The magnetic resonance relaxivities of the hybrid were examined at pH 5 and 7, simulating lysosomal and plasma conditions; the r(1) values were 7.3 and 2.9, respectively, which were highly dependent on the physiological conditions.
机译：我们通过反向胶束法成功地合成了层状双氢氧化物（LDH）血小板和GD（OH）（3）纳米槽的尺寸控制的杂交物。在受控的合成条件下，将杂交物开发成拟核 - 壳结构，其中Gd（OH）（3）纳米棒被LDH血小板组件覆盖，并通过X射线衍射和高分辨率传输研究了这一点电子显微镜。杂种的Zeta电位测量显示Gd（OH）（3）被LDH部分包围。根据动态光散射，杂种的流体动力半径均匀地控制在150nm下，其与由LDH部分围绕的一个Gd（OH）（3）纳米棒的相当。因此，所获得的杂种在5mg ml（-1）的浓度下表现出180的最大Hounsfield单元，这意味着其作为计算机断层摄影造影剂的潜力。在pH5和7中检查杂种的磁共振松弛性，模拟溶酶体和血浆条件; R（1）值分别为7.3和2.9，其高度依赖于生理条件。

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  • 来源
    《RSC Advances》 |2020年第10期|共7页
  • 作者

    Jung Sang-Yong; Gwak Gyeong-Hyeon; Park Jin Kuen; Oh Jae-Min;

  • 作者单位

    Dongguk Univ Seoul Dept Energy &

    Mat Engn Seoul 04620 South Korea;

    Pohang Univ Sci &

    Technol Pohang Accelerator Lab Beamline Res Div Pohang 37673 Gyeongsangbukdo South Korea;

    Hankuk Univ Foreign Studies Dept Chem Yongin 17035 South Korea;

    Dongguk Univ Seoul Dept Energy &

    Mat Engn Seoul 04620 South Korea;

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  • 正文语种 eng
  • 中图分类 化学;
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