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首页> 外文期刊>RSC Advances >Antibacterial potential of Ni-doped zinc oxide nanostructure: comparatively more effective against Gram-negative bacteria including multi-drug resistant strains
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Antibacterial potential of Ni-doped zinc oxide nanostructure: comparatively more effective against Gram-negative bacteria including multi-drug resistant strains

机译：Ni掺杂氧化锌纳米结构的抗菌电位：对革兰氏阴性细菌相对更有效，包括多毒性株

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摘要

Infections by multidrug-resistant (MDR) bacteria are one of the most threatening concerns for public health. For this purpose, nanomaterials have emerged with great potential for antibacterial activity. In this paper, we report the synthesis of new Ni2+-doped zinc oxide (Ni-ZnO or NZO) nanostructures as targeted antibacterial agents for Gram-negative bacteria. A one-pot low-temperature solution process was used with varying compositions containing 2 or 5% Ni2+ relative to Zn2+, resulting in 2NZO or 5NZO, respectively. X-ray diffractometry, transmission electron microscopy, and X-ray photoelectron spectroscopy were used for material characterization. Further, the antibacterial activity against both Gram-negative [Escherichia coli (E. coli) and Acinetobacter baumannii (A. baumannii) strains including standard, MDR, and clinical isolates associated with mcr-1 gene] and Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) bacteria were evaluated through analysis of zone of inhibition, minimum inhibitory concentration (MIC), and scanning electron microscopy images. Among the prepared nanostructures, the 5NZO sample showed excellent antibacterial activity against MDR strains of A. baumannii and E. coli. In addition, samples of NZO generated approximately 7 to 16 times more reactive oxygen species (ROS) in E. coli compared to ZnO. Our synthesized nanomaterials have the potential to fight MDR and colistin-resistant Gram-negative bacteria.
机译：多药抗性（MDR）细菌感染是公共卫生最威胁的最危险的问题之一。为此目的，纳米材料具有巨大的抗菌活性可能性。在本文中，我们报告了新的Ni2 +掺杂的氧化锌（Ni-ZnO或NZO）纳米结构作为针对革兰氏阴性细菌的靶向抗菌剂的合成。一罐低温溶液方法与相对于Zn2 +的2或5％Ni2 +的改变组合物一起使用，得到2nzo或5·5次。 X射线衍射测定法，透射电子显微镜和X射线光电子能谱用于材料表征。此外，针对革兰氏阴性的抗菌活性[大肠杆菌（大肠杆菌）和肺杆菌（A. baumannii）菌株，包括标准，mdr和与mcr-1基因相关的临床分离物]和克阳性（金黄色葡萄球菌和通过分析抑制区，最小抑制浓度（MIC）和扫描电子显微镜图像来评估葡萄球菌表皮）细菌。在制备的纳米结构中，5NZO样品对A.Baumannii和大肠杆菌的MDR菌株显示出优异的抗菌活性。此外，与ZnO相比，NZO的样品在大肠杆菌中产生约7至16倍的反应性氧物质（ROS）。我们合成的纳米材料具有对抗MDR和耐菌革兰阴性细菌的可能性。

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