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首页> 外文期刊>RSC Advances >High-throughput liquid chromatography mass-spectrometry-driven lipidomics discover metabolic biomarkers and pathways as promising targets to reveal the therapeutic effects of the Shenqi pill
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High-throughput liquid chromatography mass-spectrometry-driven lipidomics discover metabolic biomarkers and pathways as promising targets to reveal the therapeutic effects of the Shenqi pill

机译：高通量液相色谱法质谱型脂质族学发现代谢生物标志物和途径作为揭示神奇丸的治疗效果的有前途的靶标

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摘要

Lipidomics, a branch of metabonomics, could provide a powerful technique for discovery of lipid molecules to reveal disease status and drug efficacy. The Shenqi pill (SQP) is a representative prescription for clinical application in the prevention and treatment of kidney-yang deficiency syndrome (KYDS). However, its effect mechanism is still not clear. This article aims to reveal the intervention effect of SQP on KYDS from the perspective of lipid metabolism. In this study, SQP was used to intervene in the rat model of KYDS, on the foundation of successfully replicating the rat model of KYDS induced by corticosterone. The MetaboAnalyst tool was used for analysis of the serum metabolic profile and pattern recognition of KYDS model, based on UPLC-SYNAPT-G2-Si-HDMS. Finally, twenty-two potential lipid biomarkers related to the KYDS model were characterized, and the effects of SQP on regulating potential lipid markers in serum of KYDS model were analyzed. There were 10 biomarkers and seven metabolic pathways closely related to SQP therapy for KYDS were found. The action mechanism and targets of SQP in treating KYDS were explored based on high-throughput lipidomics. This work could provide valuable data and scientific evidence in subsequent studies for the treatment of KYDS.
机译：脂类组学，代谢组学的一个分支，可以为脂质分子的发现揭示疾病状态和药物疗效提供了强有力的技术。参芪丸（SQP）是用于预防和治疗肾阳虚综合征（KYDS）的临床应用的代表性的处方。然而，其作用机制尚不清楚。本文旨在揭示KYDS从脂质代谢的角度SQP的干预作用。在这项研究中，SQP，使用了KYDS的大鼠模型进行干预，就成功地再现了皮质酮诱导KYDS的大鼠模型的基础。所述MetaboAnalyst工具被用于血清代谢分布和KYDS模型的模式识别，基于UPLC-SYNAPT-G2-Si系HDMS的分析。最后，22相关KYDS模型的潜在生物标志物的脂质进行了表征，并分析SQP对调节KYDS模型的血清脂质的潜在标志物的影响。有10种生物标志物和七个代谢途径密切相关的SQP治疗KYDS被发现。基于高通量脂类组学在治疗KYDS SQP的作用机制和目标进行了探讨。这项工作可以在KYDS治疗后续研究提供了宝贵的数据和科学依据。

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  • 来源
    《RSC Advances》 |2020年第4期|共12页
  • 作者

    Li Wen-xiu; Zhang Ai-hua; Zhou Xiao-hang; Nan Yang; Liu Qi; Sun Hui; Fang Heng; Wang Xi-jun;

  • 作者单位

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Dept Pharmaceut Anal Engn Res Ctr Efficacy Evalua Metabol Lab Natl Chinmedom Res Ctr Minist Educ Natl TCM Key Lab Serum Pharmacochem Sino Amer Chi Heping Rd 24 Harbin 150040 Peoples R China;

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