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首页> 外文期刊>RSC Advances >Core-shell particles and monolithic columns; tools for simultaneous LC analysis of avanafil, sildenafil, apomorphine, trazodone, yohimbine, tramadol and dapoxetine in pharmaceutical dosage forms, counterfeit products and human plasma
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Core-shell particles and monolithic columns; tools for simultaneous LC analysis of avanafil, sildenafil, apomorphine, trazodone, yohimbine, tramadol and dapoxetine in pharmaceutical dosage forms, counterfeit products and human plasma

机译：核心壳颗粒和整体柱; 用于同时LC分析的工具，Sildenafil，Abomorphine，Trazodone，yohimbine，曲马多，曲马多和拟毒素在药物剂型，假冒产品和人血浆中

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摘要

By 2025, it's estimated that 322 million males worldwide will suffer from sexual disorders. This can give an estimation for the size of the pharmaceutical and counterfeit products industry for the next few years. Meanwhile, green analytical chemistry forced itself to decrease the massive environmental pollution and hence new analytical methodologies are needed to replace the old ones that consume large amounts of hazardous solvents. In this research, two new methods were validated for determination of seven recognized drugs used in treatment of male impotence, premature ejaculation as well as enhancing sexual libido by HPLC on RP-C18 core-shell particulate and monolithic columns. The study was extended to compare the capabilities of those stationary phases to accommodate greener chromatography concepts without loss of efficiency. Both morphologies shortened the analysis time relative to the previously reported conventional HPLC methods by different approaches. Core-shell particles had higher efficiency in terms of theoretical plates' number and enhanced resolution power which enabled lower detection limits. However, the monolithic column had lower column backpressure which enabled the use of ethanol as a greener alternative solvent at even higher flow rates. The methods were finally applied successfully for the determination of drugs under study in pharmaceutical dosage forms, counterfeit products and in human plasma.
机译：到2025年，据估计，全球3.22亿男性将患有性障碍。这可以估计未来几年制药和假冒产品行业的规模。同时，绿色分析化学强迫自身降低巨大的环境污染，因此需要新的分析方法来取代消耗大量危险溶剂的旧分析方法。在本研究中，验证了两种新方法，用于测定用于治疗雄性阳痿，早泄的射精，早熟射精的七种识别药物，以及通过HPLC在RP-C18核 - 壳颗粒和整体柱上增强性欲。延长了该研究以比较这些固定阶段的能力，以适应更环保的色谱概念而不会损失效率。两种形态通过不同的方法相对于先前报道的常规HPLC方法缩短了分析时间。核心壳颗粒在理论板的数量方面具有更高的效率，并增强了能够降低检测限的分辨率功率。然而，整体柱具有较低塔的背压，使得在更高的流速下使乙醇作为更环保的替代溶剂。最终将该方法成功地应用于药物剂型，假冒产品和人血浆的研究中的药物测定。

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  • 来源
    《RSC Advances》 |2020年第3期|共9页
  • 作者

    Ibrahim Adel Ehab; Hashem Hisham; Elhenawee Magda; Saleh Hanaa;

  • 作者单位

    Port Said Univ Fac Pharm Pharmaceut Analyt Chem Dept Port Said Egypt;

    Zagazig Univ Fac Pharm Pharmaceut Analyt Chem Dept Zagazig Egypt;

    Zagazig Univ Fac Pharm Pharmaceut Analyt Chem Dept Zagazig Egypt;

    Zagazig Univ Fac Pharm Pharmaceut Analyt Chem Dept Zagazig Egypt;

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  • 正文语种 eng
  • 中图分类 化学;
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